Activated antigen-specific B-cells are viewed as very potent antigen-presenting cells (APC) that can endocytose, process and present antigen at least 10 000-fold more efficiently than other professional APC, (5) largely because B-cells can selectively internalize antigen through the B-cell receptor, and efficiently stimulate T-cells through co-stimulatory molecules such as CD80 and CD86
(which are ligands for CD28 and CTLA-4 expressed on T-lymphocytes).
90) CTLA4-Ig binds to both CD80 and CD86
on the surface of antigen-presenting cells and blocks their binding to the T cell CD28, thereby inhibiting costimulation.
He also stated, "The combination of CpG and GM-CSF is synergistic for the induction of other critical co-stimulatory molecules on the surfaces of dendritic cells required for their function including CD86
It has increased binding to CD80 and CD86
, which stops T-cell response.
The relationship between CD86
and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells.
MMP-13-silenced DCs and control DCs were analyzed for surface expression of CD80 and CD86
and phagocytosis capability using flow cytometry.
production and expression of costimulatory molecules CD86
and MHCII were unaffected by loss of HIF-2[alpha], but Imtiyaz and coworkers found profound changes in cytokine mRNA expression and protein release after stimulation with LPS and interferon [gamma] (IFN[gamma]).
The cells were then incubated with FITC-conjugated antimouse MHC class II, CD86
, CD83, CD4, and CD8 antibodies or PE-conjugated antimouse MHC class 1, CD40, CD80, and CD3 antibodies, or isotype controls were incubated for 30 min at 4[degrees]C in the dark.
Abatacept competitively binds to CD80 or CD86
on antigen presenting cells, which therefore cannot bind to CD28 on T cells, inhibiting successful T cell activation.
46) hBD-3 induces the expression of CD80, CD86
, and CD40 on myeloid dendritic cells through Toll-like receptors 1 and 2.
However, CD40, CD83 and CD86
on the EBV-treated group could be up-regulated markedly (Fig.
La subpoblacion de Treg CD8+ CD28-tambien actua sobre las CDs, disminuyendo la expresion de moleculas co-estimuladoras dependientes de NF-Kb, tales como CD40, CD80, CD86
y CD58 e incrementando la expresion de receptores inhibitorios como "immunoglobulin like transcript" 3 (ILT3) e ILT4, promoviendo que aquellas Th CD4 + que interactuen con estas CDs se conviertan en celulas anergicas (16).