CD8 cells


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Related to CD8 cells: T cells, CD8 alpha, CD4 cells

CD8 cells

T cells with CD8 on the surface, which are immunosuppressive and suppress mitogen-induced and antigen-specific antibody production, and require CD4 cell cooperation
References in periodicals archive ?
TAT2 (GRN 163L), a small-molecule telomerase activator, "modestly" retarded telomere shortening while enhancing antiviral activity of CD8 cells collected from people with HIV.
The CD8 cells of long-term nonprogressors produce more perforin than do CD8 cells of HIV-positive people who developed AIDS, the scientists found.
These findings undermine the current belief that, with HIV infection, both CD8 cells and CD4 cells die and undergo a rapid turnover in the body, according to the researchers.
For people infected with HIV, the study reinforces the push for early treatment to hold down the amount of virus and thereby conserve CD8 cells, Giorgi said.
The team also found that SIV creates such mutants in response to the assault by CD8 cells at about the same rate as HIV does.
These are CD4 cell factors that are necessary to turn on the CD8 cells (cytotoxic T lymphocytes).
Three research groups now challenge that dogma with evidence showing that under certain conditions, CD8 cells can make the CD4 protein and consequently become infected by the AIDS virus.
TAT0002 was previously shown to stimulate the production of IFN-gamma -- a molecule involved in the anti-viral response of cytotoxic CD8 T-cells specific for the HIV-1 AIDS virus -- and to enhance the ability of the CD8 cells to proliferate and kill HIV-1-infected CD4 cells.
The engineered stem cells developed into a large population of mature, multifunctional HIV-specific CD8 cells that could specifically target cells containing HIV proteins.
Levy and others quickly established that CD8 cells can secrete one or more soluble molecules that hinder HIV.
Effros and colleagues demonstrated that introducing the telomerase gene into CD8 cells from HIV/AIDS donors increased: 1) their proliferative capacity, 2) their ability to produce IFN-gamma, and 3) their ability to inhibit virus production and kill HIV-infected T-cells.
They treated the CD8 T-cells with TAT2 and combined them with the CD4 T-cells in the dish-and found that the treated CD8 cells inhibited production of HIV by the CD4 cells.