cytotoxic T cell

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cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Cytotoxic T-cells, also referred to as CD8 T-cells, are required to target and eliminate pathogen-infected or cancerous cells.
Later on--anywhere from 14-75 years after vaccination--many individuals still maintained both CD4 and CD8 T-cell memory, although at lower levels than before.
As immuno-oncology research advances, it's becoming clear that CD8 T-cell imaging has significant potential in aiding the selection and monitoring of patients receiving immunotherapies," added Dr.
Why are peripheral blood CD4 T-cell counts more affected than peripheral blood CD8 T-cell counts?
Data from INSPIRE 2 HIV Study Show That CYT107 Administration Can Significantly Expand CD4 and CD8 T-cells with Lower Expression of PD-1 While Increasing the Expression of Gut Homing Molecules That May Result in the Restoration of the CD4 T-cell Population of the Gut Mucosa
Inovio's HIV DNA vaccine together with the CELLECTRA device significantly increased the number of responders producing robust and durable CD4 and CD8 T-cell responses in humans.
CD4 T-cell and CD8 T-cell responses are very evident both in the 1/10th dose and full-dose vaccine recipients
His group was the first to define the CD4 and CD8 T-cell responses to HBV in infected patients, and to demonstrate that viral clearance occurs in the context of a vigorous multi-specific T cell response, while a weak or narrowly focused T cell response to the viral antigens leads to viral persistence.
In a study directed by investigators at the Gladstone Institute of Virology and Immunology in San Francisco, CA, RC in untreated patients was positively correlated with CD8 T-cell activation, a known determinant of immune system status.
This exciting study follows favorable observations from the administration of TGF alpha to a sick, but non-SIV-infected rhesus monkey which showed an 88% increase in CD4 T-cell counts and increases in CD8 T-cells as well as CD4/CD8 T-cell precursor cells in response to the treatment," commented Dr.
Among responders to treatment, there was a significant increase in T-cell activation and in both CD4 and CD8 T-cell levels compared to pre-treatment levels.
Once HCV enters the cells and starts producing virus, CD4 and CD8 T-cell immunity appear to play a major role in combating the infection, while antibody responses appear to be less important.