cytotoxic T cell

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Related to CD8 T cells: CD4 T cells, Cytotoxic T lymphocytes

cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Patients with lung cancer who had a lot of CD8 T cells in their tumours were also more likely to have lots of a specific type of these cells, known as a 'tissue-resident' T cell.
To quantify the number of CD38 molecules by flow cytometry, the methods used are based upon the mean or median fluorescence value for CD8 T cells gated onto a CD38 histogram.
The authors concluded that this study indicated that each of the three herbs activated CD4 T cells and CD8 T cells, and that this immune activation appeared greater when all three herbs were taken together.
Indeed, a consensus is that if the immune system is still fairly intact, therapy interruption might indeed boost CD8 T cell responses, which likely contain HIV longer.
The interim results, Recombinant Human Interleukin-7 (CYT107) Enhances CD4 and CD8 T Cell Recovery Following T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplant In Patients with Myeloid Malignancies (Abstract 674), were presented by Dr.
It does this by putting helper T cells into a suppressed stage, limiting their ability to assist CD8 T cells, said Andrew Zloza, MD, PhD, one of the leading authors of the study.
CD8 T cell CD38 expression is hugely increased in HIV infection [34] and has been shown to be an important prognostic marker in patients before they start ART, independent of CD4 count and viral load [36].
The researchers traced the immune onslaught to shock troops known as CD8 T cells.
Expansion of pre-terminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption.
Studies in rhesus monkeys have shown that significant and persistent virus-specific T cell responses can be elicited with vaccines incorporating viral genetic sequences and that these responses are primarily mediated by CD8 T cells.
A new study suggests that it is the quality, not the number, of HIV-fighting CD8 T cells that distinguish rare HIV nonprogressors from progressors.
Study indicates rhIL-7 blocks sepsis-induced depletion of CD4 and CD8 T cells, enhances lymphocyte recruitment and prevents sepsis-induced loss in immunity leading to improved survival