cytotoxic T cell

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Related to CD8 T cell: CD4 T cells, Memory T cells

cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Professor Lalvani said that the immune system produces these CD8 T cells in response to usual seasonal flu.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that CD8 T cell activation defined by CD38 expression was the strongest predictor of clinical progression [4].
These new assays were based on measuring antigen-specific cytokine production in both CD4 and CD8 T cells from HIV-infected people.
As in the study reviewed here, this development and expansion of CD4 and CD8 T cells appears to result in an immune system recovery which may be associated with a lower incidence of opportunistic infections and a longer life expectancy, a clinical benefit that we hope to demonstrate in future large-scale randomized clinical studies.
CD38 expression on CD8 T cells with or without other markers (HLA DR and CD45RA) is not adequate to predict the virological response to antiretroviral therapy (ART) in Ugandans: XVI International AIDS Conference Toronto (Abstr.
Evaluate whether any observed changes in CD4 and CD8 T cell counts are due to increasing thymic output and/or peripheral T cell expansion
After 48 weeks, patients treated at the higher dose level showed a median increase in CD4 and CD8 T cell counts (cells/microliters) of 75% and 58%, respectively, from baseline levels.
The study data also showed enhanced HIV-specific CD4 and CD8 T cell activity in these patients.
The vaccine is aimed at inducing strong and persistent HIV-1 gag specific CD8 T Cell responses.
One study revealed mostly similar distributions of CD4 and CD8 T cell subsets in LTNPs and patients in the early phase of infection (Clin Diagn Lab Immunol, 5:5, p.
Researchers in France compared CD8 T cell responses from 24 patients with documented PHI to CD8 responses from 30 asymptomatic HIV-infected patients who were antiretroviral treatment naive (Abstract 573).
This new study follows positive results from a recently completed study conducted by NIH in collaboration with Kaleidos Pharma demonstrating that TGF alpha increased both CD4 and CD8 T cell counts in SIV-infected monkeys.