cytotoxic T cell

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Related to CD8+ T cells: lymphocyte activation

cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression.
Oral administration resulted in a more potent anti-angiogenesis effect, but effector function of CD8+ T cells was more significantly increased by the intratumour injection.
Influenza-specific CD8+ T cells recognize multiple viral epitopes on target cells and antigen-presenting cells.
The researchers found that CD8+ T cells of people who could not control HIV retained only a limited ability to divide and produce perforin.
The Capcellia assays of CD4+ and CD8+ T cells in the controls and the samples mixed with the magnetic beads also indicated that practically all ([greater than or equal to]96%)the CD4+ and CD8+ T cells had been removed from the samples, confirming the efficiency of T-lymphocyte capture by the magnetic phase.
Joseph Kim, President & CEO of Inovio, said, "These results show the ability of our HIV immune therapy to activate HIV-specific CD8+ T cells in infected patients and the potential to go beyond virus control and reach into reservoirs of the infection to halt progression of HIV.
Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells (less than 5 percent), plays a specialized role in protecting from lupus.
HLA-DR expression is massively increased on both CD4+ and CD8+ T cells in untreated HIV infection and falls with successful ART [40,41].
With many resource-limited areas of the world now gaining access to more affordable anti-retroviral therapies, simpler and less costly methods of monitoring treatment -- including absolute CD4+ and CD8+ T cell counts -- are urgently needed," said Barry Bredt, Ph.
The Phase 1 study will also evaluate whether the immunotherapy will restore the central and effector memory CD8+ T cell phenotype as demonstrated in earlier studies using product generated from leukapharesis of ART-suppressed individuals.
We noted that the cells were responsive to osteopontin but also that they expressed what we knew to be the target of suppressor CD8+ T cells," said Cantor.