The antiviral capacity of these virus-specific CD8+ cells
is strongly dependent on their ability to migrate and localize to the lungs and infected airway epithelium (14), where they appear 5-7 days after infection (15).
Using the statistical analysis of Lehmacher (SAL), however, a significant difference after 1 week of treatment was found in the number of CD8+ cells
Effros and colleagues demonstrated that introducing the telomerase gene into CD8+ cells
from HIV/AIDS donors increased their proliferative capacity, their ability to produce IFN(gamma), and their ability to inhibit viral replication and kill HIV-infected T-cells.
Their teams determine relevant antigens within infected cells, which subsequently will be used to identify characteristic parts of these proteins (epitopes) that are required by the CD8+ cells
to activate the immune response against these bacteria.
The data also suggests an increase in CD8+ cells
in the Ampligen group suggesting an induction of immune cells that have potential to seek and may destroy cells infected with HIV.
Changes in CD4+ cells, CD8+ cells
and body weight were monitored at each patient visit.
The TCell-DLI Cell Separation System is an ex-vivo system for removal of CD8+ cells
from donor leukocyte infusions.
There are also a number of Isolex(R) systems currently in use in investigational protocols for gene therapy and dendritic cell therapy, engineered transplants with alternative donors and for autoimmune diseases, and depletion of specific T-cell subsets such as CD4+ or CD8+ cells
In order to evaluate if CD8+ cells
were responsible for the increased protection, SCID mice were reconstituted with cells after depletion of CD8+ cells
, either from a normal donor or an HGP-30 vaccinee.