Type 17 CD8+ T cells
display enhanced antitumor immunity.
Elevated CD38 antigen expression on CD8+ T cells
is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression.
Oral administration resulted in a more potent anti-angiogenesis effect, but effector function of CD8+ T cells
was more significantly increased by the intratumour injection.
Influenza-specific CD8+ T cells
recognize multiple viral epitopes on target cells and antigen-presenting cells.
The researchers found that CD8+ T cells
of people who could not control HIV retained only a limited ability to divide and produce perforin.
The Capcellia assays of CD4+ and CD8+ T cells
in the controls and the samples mixed with the magnetic beads also indicated that practically all ([greater than or equal to]96%)the CD4+ and CD8+ T cells
had been removed from the samples, confirming the efficiency of T-lymphocyte capture by the magnetic phase.
Joseph Kim, President & CEO of Inovio, said, "These results show the ability of our HIV immune therapy to activate HIV-specific CD8+ T cells
in infected patients and the potential to go beyond virus control and reach into reservoirs of the infection to halt progression of HIV.
Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells
(less than 5 percent), plays a specialized role in protecting from lupus.
HLA-DR expression is massively increased on both CD4+ and CD8+ T cells
in untreated HIV infection and falls with successful ART [40,41].
With many resource-limited areas of the world now gaining access to more affordable anti-retroviral therapies, simpler and less costly methods of monitoring treatment -- including absolute CD4+ and CD8+ T cell
counts -- are urgently needed," said Barry Bredt, Ph.
The Phase 1 study will also evaluate whether the immunotherapy will restore the central and effector memory CD8+ T cell
phenotype as demonstrated in earlier studies using product generated from leukapharesis of ART-suppressed individuals.
We noted that the cells were responsive to osteopontin but also that they expressed what we knew to be the target of suppressor CD8+ T cells
," said Cantor.