CD8


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CD8

a type I transmembrane protein found on suppressor (cytotoxic) T cells, some natural killer cells, and most thymocytes that is involved in T-cell antigen recognition; expressed in some T-cell lymphomas and large granular lymphocyte leukemias.

CD8

(sē′dē-āt′)
n.
A glycoprotein on the surface of killer cells that enhances binding with MHC molecules.

CD8

T8 antigen A disulfide-linked heterodimeric protein, for which each monomer is 32–34 kD; CD8 is a marker for T cells with suppressor and cytotoxic activity; it is a co-receptor with class I MHC antigens on antigen-presenting cells, and is physically associated with a p56 tyrosine kinase, which phosphorylates adjacent proteins; NK cells may weakly express CD8. See Cytotoxic T cells.

CD2

cluster of differentiation or cell differentiation glycoproteins.

CD antigen
a group of cell surface molecules which act as markers on T lymphocytes.
CD3
found on T helper (Th) and T cytotoxic (Tc) lymphocytes; associated with signal transduction.
CD4
found on T helper lymphocytes; an adhesion molecule that binds to class II MHC molecules.
CD8
found on T cytotoxic and variably on NK lymphocytes; an adhesion molecule that binds to class I MHC molecules.
References in periodicals archive ?
c, The sinusoids showing strong immunoreactivity for CD8.
A number of studies have put forward the hypothesis that increased expression of CD38 (by rapidly proliferating CD4 and CD8 memory T cells in retroviral illness) is a compensatory mechanism aimed at scavenging nucleotides to prevent apoptosis from nucleotide starvation [44-45].
The authors concluded that this study indicated that each of the three herbs activated CD4 T cells and CD8 T cells, and that this immune activation appeared greater when all three herbs were taken together.
One avenue that we believe would be productive for further investigation is whether or not CD4 and CD8 counts and CD4:CD8 ratios would be valuable prognostic indicators in patients with B-CLL, as proposed by Hermann et al (4) in 1982.
This notion is complicated because there is preferential HIV infection of HIV-specific CD4 T cells, perhaps crippling future HIV-specific antibody and/or CD8 responses.
Later on--anywhere from 14-75 years after vaccination--many individuals still maintained both CD4 and CD8 T-cell memory, although at lower levels than before.
When leukocytes were stained with several fluorescein-labeled antibodies, CD3, CD8, CD45, and CD45RA, the spectra of the stained cells shift further to the red with respect to those of the antibodies (Fig.
By measuring how the lengths of CD4 telomeres changed over a nine-year period, in comparison to how CD8 telomeres changed, the researchers were able to tell how fast both types of cells replicated.
In addition to providing further evidence of the ability of IL-7 to stimulate the expansion of CD4 and CD8 T-cells in peripheral blood, the results demonstrate the importance of IL-7 in stimulating T-cell repopulation of the lymphoid tissue layer in the mucous membrane of the GI tract.
Lalvani said: "The immune system produces these CD8 T cells in response to usual seasonal flu.
All white blood cells have CD45 receptors, but only subsets have other receptors such as CD20, CD3, and CD8.