CD71

CD71

a type II transmembrane protein present on activated or proliferating cells that facilitates cellular iron uptake; expressed in many acute leukemias and some lymphomas.

TFRC

A gene on chromosome 3q29 that encodes transferrin receptor, a protein required for development of erythrocytes and the nervous system.
References in periodicals archive ?
The FC studies we conducted showed that CD38, CD71, and CD30 were positive in 100% of PELs.
United States-based CytomX Therapeutics has advanced CX-2029, a probody drug conjugate aimed at CD71, which is highly attractive for delivery of cytotoxic payloads to cancer cells, it was reported on Friday.
CytomX Therapeutics teamed up with AbbVie to co-develop and commercialize Probody Drug Conjugates against CD71, which is highly expressed in a number of solid and hematologic cancers and has molecular properties for efficient delivery of cytotoxic payloads to tumor cells.
Furthermore, upregulated expression of CD71 is considered as a marker of poor prognosis in breast cancer patients [28].
CD71 is highly expressed in a number of solid and hematologic cancers and has attractive molecular properties for efficient delivery of cytotoxic payloads to tumor cells.
BMSCs express a number of nonspecific markers as CD105 (SH2), CD73 (SH3/4), CD44, CD90 (Thy-1), CD71, and Stro-1, as well as the adhesion molecules CD106 and CD166, intercellular adhesion molecule1, and CD29 [17].
In the case presented, the myeloblasts were positive for CD34 (Image 3B), megakaryocytes were identified by factor VIII related antigen and CD71 highlighted erythroid precursors (not shown).
The analysis (fluorescence-activated cell sorting, FACS) was performed using CD29, CD34, CD71, and CD90 as primary fluorescent antibodies and using IgG-FITC and IgG-PE as secondary antibodies.
These still-developing cells, which have a protein on their surface called CD71, also show up in abundance in the umbilical cord blood of human babies, the team showed.
9 In most cases the blasts are positive for CD34, CD56, CD117, CD13, CD33, CD7, CD4 (dim), CD4, CD42, TPO-R, CD36, CD61 and CD71.