CD69


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Related to CD69: CD25, CD44

CD69

a type II transmembrane protein present on platelets, CD4-positive or CD8-positive thymocytes, activated lymphocytes, and activated T or natural killer cells that functions as a signal transducer, enhancing cell activation and/or platelet aggregation.

CD69

A gene on chromosome 12p13 that encodes a member of the calcium-dependent lectin superfamily of type-II transmembrane receptors, the expression of which is induced by T-cell activation. CD69 is involved in lymphocyte proliferation and acts as a signal-transmitting receptor in lymphocytes, natural killer (NK) cells and platelets.
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Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure.
CD69 was positive in all cases but was of variable intensity, ranging from dim to bright, without any obvious pattern.
10,12), this assay detects the activation marker CD69 on the surface of CD3+ T cells, correlates well with skin test reactivity, and indicates previous (or current) exposure to Coccidioides spp.
Interestingly, CD69 expression was significantly high at early time point in TB-PMN compared to normals.
The main objective of the study was to determine if each herb increased CD69 expression when administered orally for seven days.
The expression and function of the CD69 antigen was compared between healthy elderly and young subjects.
In sepsis, upregulated expression of CD80, CD86, CD25, and CD69 and the increased concentration of serum proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1[sz] indicate immune activation.
In addition, SLE patients also exhibited decreased levels of the inhibitory receptor NKG2A and increased levels of the activating receptors CD69 and HLA-DR on [gamma][delta] T cells [74].
Cultured cells were washed with PBS and stained with fluorescein isothiocyanate (FITC)-labeled antihuman CD69 mAbs, R-phycoerythrin (PE)-labeled anti-human CD25 mAbs (IL-2 receptor) and allophycocyanin (APC)-labeled anti-human CD4 or CD8 mAbs for 15 min at 4[degrees]C (all antibodies were purchased from eBioscience).
In a study involving 72 participants, including 36 patients with moderate-to-severe AD versus a control group of 36 healthy individuals, the expression of the marker CD69 on specific sub-populations of lymphocytic cells was statistically significantly lower in the AD groups compared to the control group, as measured under two different stimulation conditions (LymPro Version 1 and LymPro Version 2).
V] comparten ciertas caracteristicas fenotipicas: son celulas mas pequenas y con cromatina mas condensada que los linfocitos T efectores, poseen bajos niveles de ARN mensajero (ARNm) y carecen de marcadores de activacion, como CD69.