CD59


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CD59

a glycosylphosphatidylinositol-anchored membrane protein present on many hemopoietic cells, vascular endothelium, epithelial cells, and placenta that inhibits membrane complement attack and may be involved in T-cell signal transduction; absent or defective in paroxysmal nocturnal hemoglobinuria.

CD59

A 65-kD membrane, glycosyl-phosphatidylinositol-anchored complement-neutralising protein encoded by CD59 on chromosome 11p13, which inhibits the complement membrane attack complex, binding to C8 and C9 during assembly of the complex.

Normal expression
Most leukocytes and red cells.

Abnormal expression
May be absent in some forms of paroxysmal nocturnal haemoglobinuria.
References in periodicals archive ?
C8[alpha] is also recognized by CD59, a complement regulatory protein that protects human cells by binding C8[alpha] and C9 and inhibiting formation of the MAC.
As it replicates inside cells, it takes on the CD59.
In an effort to understand the pathogenesis of anaemia in Pf infection we studied the relationship between expression level of CD35, CD55 and CD59 with haemoglobin status in a group of malaria cases from three regions of India, namely Assam, Goa and Chennai.
Both our Trop-2 and CD59 antibody programs have demonstrated novel approaches in treating cancer.
Expression of human complement regulatory protein, such as hDAF, CD46, and CD59, on endothelial cells was critical for protection against HAR in xenotransplantation because the endothelial cells are first exposed to the various components of the recipient's immune system (Aigner et al.
Led by senior author Rajendra Kumar-Singh, PhD, the researchers demonstrated for the first time that CD59 delivered by a gene therapy approach significantly reduced the uncontrolled blood vessel growth and cell death typical of AMD, the most common cause of blindness in the elderly.
These proteins include (i) calcium-binding protein MRP14 implicated in several types of cancer; (ii) CD59 overexpressed on tumour cells that enables them to escape from complement-dependent and antibody-mediated immune responses; (iii) Profilin 1, a protein involved in several signaling pathways with cytoplasmic and nuclear ligands, generally secreted into tumour microenvironments during the early progressive stage of tumorigenesis; and (iv) catalase, a member of the enzymatic antioxidative system, whose level is elevated in many human tumours and involved in carcinogenesis and tumour progression (109).
One way HIV evades immune attack is by hijacking one of these proteins - CD59 - and using it to disguise itself and the cells it infects as healthy, human cells.
Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituxumab in vitro: CD55 and CD59 regulate complement-mediated cell lysis.
Antibodies to CD55 and CD59 are specific for decay-accelerating factor and membrane-inhibitor of reactive lysis, respectively, and can be analyzed by flow cytometry to make a definitive diagnosis of PNH (29, 3335).
Fourteen differentially expressed genes (AREG (Amphiregulin), ATRN (Attractin), CD59 (CD59 molecule), CLU (Clusterin), CST3 (Cystatin C), DPEP1 (Dipeptidase), EPHX1 (Epoxide hydrolase), LEAP2 (Liver expressed antimicrobial peptide 2), LOC396871 (Arginine rich antibacterial peptides), MS4A2 (Membrane-spanning 4-domains), PIAP (Putative inhibitor of apoptosis), RETN (Resistin), UBP (Ubiquitin-specific protease), FBP (Folate binding protein) dentified in the array experiment were selected and analyzed by RT-qPCR.