CD57


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CD57

a membrane protein present on natural killer cells, some T cells, a few B cells, and monocytes of unknown function; expressed in large granular lymphocyte leukemias.

CD57

A glucuronyltransferase encoded by B3GAT1 on chromosome 11q25 which is involved in the biosynthesis of the L2/HNK-1 carbohydrate epitope on glycoproteins, and which also plays a role in glycosaminoglycan biosynthesis.

Normal expression
NK cells, oligodendrocytes, Schwann cells, gastric chief cells, gut chromaffin cells, pancreatic islets, renal proximal tubules and loop of Henle, prostatic epithelium, adrenal medulla, epithelial cells of outer thymic cortex, and some fetal bronchial cells.

CD57

A cell surface antigen expressed on many natural killer cells.
See: cluster of differentiation
References in periodicals archive ?
The amount of natural killer cells with an outer CD57 marker can decrease with the presence of Lyme disease, but Babesia, when it is killed, can decrease the levels of this type of cancer killer cell even more.
Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer.
42] Neuron-specific enolase (NSE) (25-100%), chromogranin A (22-89%), synaptophysin (67-76%), CD57, CD56, and protein gene product 9.
10-12) Typical immunohistochemical findings include positivity for vimentin, CD99, FLI1, and variable reactivity for neuron-specific enolase, CD57, synaptophysin, and cytokeratin.
The neoplastic cells were negative for CD4, CD8, CDT, CDS, CD57, CD20, ALK-1, and Epstein-Barr virus (EBV).
Upon further characterization, the atypical lymphoid infiltrate was positive for CD3, CD56, TIA-1, and granzyme-B, characteristic of NK cells or activated T lymphocytes, and was negative for CD57 (Figure 2).
Poor recovery of CD4+ T cells in HIV patients on ART correlates with elevated expression of CD38, HLA-DR, Ki67 and CD57 on T cells [6,17,26,27] and increased rates of CD4+ T cell turnover [25].
Bone marrow biopsy revealed 40 to 50% cellularity with involvement by a T-cell lymphoproliferative disorder of TCR-gamma/delta immunophenotype positive for CD2, CD3, CD5dim, and CD7dim and negative for CD4, CD8, CD16, CD25, and CD56, with variable CD57 expression.
Certain PCR tests that use less than 10 BP for primers; some Lyme culture tests; lymphocyte transformation tests; over/ sensitized ELISA/IFA tests; quantitative PCR test; dark field microscopy; some other direct visualization tests Some ancillary tests to address health status include: salivary hormone testing, nutritional profiles, provoked metal testing, stool health tests, organic acids testing, methylation testing, kryptopyrrole testing, MELISA testing, CD57 testing, IgG allergy testing, autoimmune testing, urine amino acids testing, hair testing, saliva/stool antigen testing, and mycotoxin testing Mainstream Treatment Lyme-Literate Treatment Treat for 10-28 days Treatment is based on clinical response.
NK-cell lymphomas express CD2, CD7, CD8, CD56 and CD57 - all of which are also observed in certain subgroups of T-cells.
CD57 is a useful marker for the diagnosis of metanephric adenoma.
S-100 protein, HMB-45 (gp100), tyrosine, melan-A, microphthalmia transcription factor, vimentin, neuron-specific enolase, CD117, CD99, synaptophysin, CD56, and CD57 stains have all been identified in malignant melanoma,.