To address these shortcomings, Pomerantz and colleagues obtained surgical biopsies of muscles of the head, trunk and leg, and used antibody staining to show that human satellite cells can be identified by their co-expression of the transcription factor PAX7 with surface proteins CD56
CD3, CD4, CD9, CD11, CD19, CD20, CD22, CD26, CD27, CD28, CD29, CD33, CD37, CD40, CD44, CD45, CD47, CD52u CD55, CD56
, CD66, CD70, CD74, CD80, CD95, CD98, CD100, CD117, CD135, CD137, CD152, CD200, CD223, CD227, CD246, CD248, CD274, CD276, CD279
The tumour cells were immunohistochemically positive for cytokeratin (CK) AE1/AE3, CK7, synaptophysin and CD56
These cells called uterine NK (uNK) cells are characterized by a high expression of CD56
Markers that were positive included CD45/LCA (8 of 8 [100%], with variable intensity in 4 cases, CD4 (4 of 6 [67%]), TdT (2 of 3 [67%], in a subset of cells), CD31 (1 of 1 [100%]), CD34 (1 of 5 [20%]), and CD56
(1 of 2 [50%]).
There was no staining for AE1 AE3, pancytokeratin, H-caldesmon, myogenin, CK 5/6, CK14, p63, 34BE12, CD34, CK7, CD56
, EMA, S100, melan A, c-KIT and CD99.
Immunohistochemical staining showed focal positivity in the primitive neuroepithelial component for chromogranin, neuron-specific enolase, synaptophysin, and CD56
NK cell concentration was determined according to cell surface molecules using monoclonal antibodies directed against key NK cell markers: CD16 and CD56
Immunohistokimyasal incelemede sinaptofizin, kromogranin, CD56
, noron spesifik enolaz (NSE), vimentin ile hucrelerde pozitiflik izlendi, pankeratin negatifti.
However, the cells are negative for Epstein-Barr virus (EBV) and CD56
The most striking observation has been the consistent and significant expansion of a specific subset of NK cells expressing the NK cell marker CD56
at high levels ([CD56
There was no mediastinal mass, and the blasts reportedly were CD2, CD3, and CD7 positive, but there was no mention of CD4, CD8, CD56
or TdT positivity.