CD49f

CD49f

a type I transmembrane protein present on platelets, macrophages, monocytes, thymocytes, T cells, and adherent cell lines that forms a receptor for invasion and laminin; expressed in some acute lymphocytic leukemias.

ITGA6

A gene on chromosome 2q31.1 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development, differentiation and metastases. Alpha 6 binds to a beta-1 chain, forming the VLA-6 integrin, a receptor for laminin on platelets, or with beta 4 to form TSP180, a receptor for laminin in epithelial cells, which plays a critical structural role in hemidesmosome.
References in periodicals archive ?
Machida and colleagues (2012) also found that TISCs isolated from the livers of alcohol-fed HCV Ns5a transgenic mice and from alcoholic patients carried molecules called CD133 and CD49f (i.
CD49f enhances multipotency and maintains stemness through the direct regulation of OCT4 and SOX2.
Table 1 Abbreviations of the Protein Names Mentioned in This Article, Their Full Names, and Their Main Functions Acronym Full Name DNACD133 Prominin 1 CD49f Integrin [alpha] 6 ERK Extracellular signal-regulated kinase EZH2 Enhancer of Zeste homology 2 MyD88 Myeloid differentiation response gene Nanog Named after Tir NanOg legend Oct 4 Octamer-binding transcription factor 4 p21 Wafl/C.