CD48

CD48

a glycosylphosphatidylinositol-anchored membrane protein present on T cells, B cells, thymocytes, eosinophils, neutrophils, bronchial epithelium, and salivary glands that may play a role in signal transduction on T cells; absent or defective in patients with paroxysmal nocturnal hemoglobinuria.
References in periodicals archive ?
In contrast, 23 CD genes (CD3E, CD69, CD48, CD274, CD40L, CD59, CD40, CD93, CD247, CD28, CD5L, CD38, CD44, CD200R1A, CD14, CD5, CD83, CD2, CD200, CD4, CD79B, CD72, and CD180) were significantly increased by 2.
In addition, CD48 the proposed ligand for CD2, shows at least 47 different glycan structures (18).
In the comparison of B-CLL and myeloid leukemia, most of the statistically significant probes with higher hybridization signals in B-CLL samples represented B lymphocyte-associated genes, such as BTG1, CD79A, FAIM3, CCR7, CD48, and HLA-DRA (28).
5] Human genes: CD2, CD2 molecule; CD3E, CD3e molecule, e (CD3-TCR complex); LCK, lymphocyte-specific protein tyrosine kinase; GZMA, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); CD28, CD28 molecule; MNDA, myeloid cell nuclear differentiation antigen; LYN, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; MYC, v-myc myelocytomatosis viral oncogene homolog (avian); BTG1, B-cell translocation gene 1, anti-proliferafive; CD79A, CD79a molecule, immunoglobulin-associated a; FAIM3, Fas apoptotic inhibitory molecule 3; CCR7, chemokine (C-C mofif) receptor 7; CD48, CD48 molecule; HLA-DRA, major histocompatibility complex, class II, DR a; FCER2, Fc fragment of IgE, low affinity II, receptor for (CD23); CD52, CD52 molecule.
In the July 6 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, the researchers identify CD48, which adorns the surface of mast cells, as the protein that performs that binding.