CD44 antigen | definition of CD44 antigen by Medical dictionary
CD44 (redirected from CD44 antigen)
a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.
CD44 A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive
The cut-off of 22 000 ng/mL represents the mean CD44 antigen
level in the patient cohort.
The CD44 antigen
that is targeted by this antibody has been identified as a cancer stem cell marker in several different malignancies.
The best combinations for Cyp1b1 were Ahr, melanoma growth-simulating activity-alpha (Gro1) oncogene, and Cd44 antigen
with CoD of 0.