CD41

CD41

a type I transmembrane protein present on platelets and megakaryocytes; serves as a receptor for fibrinogen, fibronectin, vitronectin, von Willebrand and other factors; facilitates platelet adhesion and aggregation.
References in periodicals archive ?
Over 100 mutations that alter the expression and/or function of glycoproteins IIb-IIIa (GP IIb-IIIa, or CD41 and CD61) have been described in TG patients.
Yine tani amaci ile agregometrenin yaninda akim sitometri incelemesinde CD41 ve CD61 monoklonal antikorlari kullanilarak glikoprotein (GP) IIb-IIIa duzeylerinin normalden dusuk oldugu belirlenebilir (Sekil 1).
Are there differences between laboratories that use of fail to use the CDC's guidelines to measure CD41 and CD81 T cells?
Acute myeloid leukemia with recurrent t(1;22) generally shows evidence of megakaryocytic differentiation, which can be demonstrated by using antibodies targeting CD41 (glycophorin IIb) and CD61 (glycophorin IIIa).
The AML cases that cannot be distinguished by morphology and cytochemistry, specifically MO and M7, for which the presence of myeloid dysplasia in the former and the cytoplasmic blebs in the latter may give a hint for the probable diagnosis, however there is still the need for more positive diagnostic technique and as the flow cytometry immunophenotyping is not available then the use of a limited number of CD markers study by immunohistochemistry to identify the lineage of acute leukaemia is the option, these include CD33, anti-myeloperoxidase and CD41.
The cell enrichment methods employ reagents that specifically recognize CD9 and CD41, in conjunction with other markers expressed on lineage committed progenitor cells.
This study was undertaken to examine the tissue distribution of a broad spectrum of monoclonal antibodies (mAbs) containing tetraspan antigens (CD9, CD63, CD151), endothelial cell antigens (CD31, CD36, CD105, CD106, CD146), integrins (CD49a-f, CD29, CD41, CD51, CD61), CD39, CD98, CD99, CD143 and, CD147 supplied from fifth and sixth international workshops and conferences on human leukocyte differentiation antigens in a comparative manner in human OA and normal synovium.
5 mg/mL) 45 Platelet function- related markers, % CD41 (GPIIb) 0 CD61 (GPIIIa) 0 CD42b 100 Analyte Day 3 Reference interval WBC, x [10.
In addition to aggregometer, low than normal levels of glycoprotein (GP) IIb-IIIa can be determined with flow cytometer using CD41 and CD61 monoclonal antibodies (Figure 1).
Others (17) have reported that cases of AEL, particularly the pure erythroid leukemia subtype, can express the megakaryocyte-associated antigens CD41 and CD61.
The results of staining for CD3, CD41, CD43, CD56, CD117, and myeloperoxidase were negative.
1-conjugated CD14 (CD14-PC5), CD45-PC5, fluorescein isothiocyanate-conjugated CD41 (CD41-FITC), CD61FITC, phycoerythrin-conjugated CD62 (CD62P-PE, or P-selectin), CD154-PE (CD401igand, or CD40L), MPOFITC (all Beckman Coulter), CD162-PE (PSGL-1; BD Biosciences), TLR-2-FITC, TLR-4-PE (both Ebioscience), and COX-2-FITC (Cayman Chemical).