CD40l

CD40l

a type II transmembrane protein present on activated CD4-positive T cells, a few activated CD8-activated T cells, and blood basophils; a ligand for CD40 that induces activation, proliferation, and/or differentiation of CD40-expressing cells.

CD40LG

A gene on chromosome Xq26 that encodes of a protein expressed on the surface of T cells which regulates B-cell function by binding CD40 to the B-cell surface. CD40LG is critical for immunoglobulin class switching. 

Molecular pathology
A defect in CD40LG is associated with hyper IgM syndrome due to an inability to undergo class switch.
References in periodicals archive ?
7 CD40L (pg/mL) 84 130 184 202 235 935 ICAM-1 (ng/mL) 4 5 7 7 8 27 F3 (pg/mL) 37 53 82 68 113 394 PAI-1 (ng/mL) 60 105 120 124 146 209 ET-1 (pg/mL) 2 5 8 7 12 186 ACE-1 (ng/mL) 93 151 182 187 223 428 True-purified air Mean Variables Minimum P25 P50 (a) P75 Maximum miRNAs (b) miR-21-5p 0.
Through this T cell-B cell interaction, B cells are stimulated by T cell-derived signals such as CD40L (CD154) essential for the survival and activation of antigen-stimulated B cells, followed by differentiation to antibody-producing cells.
CD4[sup]+ Th cells are divided into two subsets (Th1 and Th2): Th1 cells release IL-2 and IFN-a, regulate CTL cells to exert their cytotoxic effects, and mediate cell immunity to clear viruses; Th2 cells secrete cytokines such as IL-4, IL-6, and IL-10 and regulate humoral immunity by expressing the costimulatory molecule CD40L and combining it with the B-cell surface CD40 receptor.
The interaction between the CD40L that is expressed on vascular cells, and soluble CD40L (sCD40L) causes inflammatory and prothrombotic responses, resulting in increased atherosclerotic progression (5,7).
Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells.
This agreement allows ImmuNext to grant Sanofi with an exclusive, worldwide license to develop and commercialise INX-021, a CD40L monoclonal antibody in preclinical development that suppresses the activity of a cellular pathway that is overactive in many autoimmune diseases.
Global Markets Direct's, 'Tumor Necrosis Factor Receptor Superfamily Member 5 (B-Cell Surface Antigen CD40 or CD40L Receptor or CD40) - Pipeline Review, H1 2016', provides in depth analysis on Tumor Necrosis Factor Receptor Superfamily Member 5 (B-Cell Surface Antigen CD40 or CD40L Receptor or CD40) targeted pipeline therapeutics.
Kits used to measure platelet function markers included: Human soluble CD40L Platinum enzyme-linked immunosorbent assay (ELISA) (Bender Med Systems, cat no: BMS265, lot no: 87059020, Vienna, Austria), Human sPS Platinum ELISA (Bender Med Systems; cat no: BMS219/4; lot no: 93950016 Vienna, Austria), HBT Assera Chrom Stago ELISA (cat no: 00950, lot no: 111398, Seine, France), and Human PF4 Assera Chrom Stago ELISA (cat no: 00951, lot no: 111112, Seine, France).
Por ejemplo, el glicolipido OCH no induce suficientes niveles de mRNA para c-rel y CD40L en las iNKT in vivo, y produce una disminucion del IFN-[gamma] secretado por las iNKT, mientras los niveles de IL-4 se conservan (59).
A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L," Proceedings of the National Academy of Sciences of the United States of America, vol.
Moreover, the soluble CD40L (sCD40L)/CD40 axis is a thromboinflammmatory mediator that affects platelet and endothelial functions.
Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients," Immunity & Ageing, vol.