CD40l

CD40l

a type II transmembrane protein present on activated CD4-positive T cells, a few activated CD8-activated T cells, and blood basophils; a ligand for CD40 that induces activation, proliferation, and/or differentiation of CD40-expressing cells.

CD40LG

A gene on chromosome Xq26 that encodes of a protein expressed on the surface of T cells which regulates B-cell function by binding CD40 to the B-cell surface. CD40LG is critical for immunoglobulin class switching. 

Molecular pathology
A defect in CD40LG is associated with hyper IgM syndrome due to an inability to undergo class switch.
References in periodicals archive ?
2 fibrosarcoma) and then treated with either Mobist, CD40L, a combination of both, or mouse serum albumin (MSA), a control protein, for 20 days starting on the day of the tumor inoculation.
Concentrations of tumor necrosis factor-a, interleukin 6 (IL-6), IL-12/23p40, IL-8, monocyte chemotactic protein 1, ILIRa, soluble CD40L (sCD40L), IL-15, interferon-g (IFN-g), IL-4, and IL-17 were determined for all samples by using the Bio-Plex 200 System (BioRad Laboratories, Hercules, CA, USA).
Transcription analysis of 44 CD genes was also carried out, indicating 24 CD genes (CD3E, CD244, CD69, CD247, CD40L, CD38, CD5L, CD44, CD5, CD83, CD163L1, CD36, CD14, CD28, CD200R1A, CD40, CD59, CD200, CD4, CD2, CD72, CD180, CD79B, and CD93) to be markedly increased by 2.
Dehydroepiandrosterone inhibits CD40/ CD40L expression on human umbilical vein endothelial cells induced by interferon gamma.
4] cells) were stained with monoclonal antibodies against toll-like receptor (TLR)-4, HLA-DR (eBioscience, Vienna, Austria), CD14, CD80, CD86, CD40 (Bio-Rad AbD Serotec, Puchheim, Germany) for DCs and against CD4, CD69, CTLA-4, CD40L (eBioscience) and CD54 (Bio-Rad AbD Serotec) for allogeneic [CD4.
Interleukin-17 (IL-17) and IL-17 Receptor Antagonists - Coagulation Factors 2009: Target Pipeline and Corporate Benchmark Analysis - CD40 and CD40L (CD154) Agonists and Antagonists - Interleukin-12 (IL-12) and IL-23 Antagonists - Interleukin-13 (IL-13) Antibodies - Syk Kinase Inhibitors - BM-CSF antibodies - Death Receptors TRAIL-R1/2
Biz, CD40/ CD40L ikilisinin indirekt bir gostergesi olan serum cozunmus CD40 (cCD40) duzeylerinin KYA ile iliskisini arastirmayi hedefledik.
54) Further experiments indicate that ligation of CD40 on CLL tumor cells by CD40L expressed on stromal cells is partially responsible for this effect.
Platelet activation was assessed by measuring changes in platelet surface expression of CD40L and CD62P and changes in the number of platelet-leukocyte conjugates relative to the baseline values of each exposure.
Membrane bound CD40L and sCD40L forms interact with the CD40 receptor molecule, which is present not only on B cells but also on monocytes, macrophages, and endothelial and smooth muscle cells in atheroma, leading to release of matrix MMPs and subsequent destabilization of the plaque (32).
CD40 ve CD40L tumor nekroz faktor super ailesine bagli bir reseptor-ligand ciftidir.
25) Since this therapy alone is not sufficient for a complete treatment of the tumor, some authors highlight the possible use--in combination- of CD40L (see index).