CD40


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CD40

a type I transmembrane protein present on mature B cells, monocytes, dendritic cells, and epithelial cells involved in signal transduction leading to cell activation, proliferation, adhesion, and/or differentiation; expressed in B-cell chronic lymphocytic leukemias, lymphomas, and some carcinomas.
References in periodicals archive ?
Human bone marrow megakaryocytes and platelets express PPAR-[gamma], and PPAR-[gamma] agonists blunt platelet release of CD40 ligand and thromboxanes.
IL-18 (-656G/T, rs1946519) and CD40 (C/T, rs1883832) SNPs were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
CD40/ CD40 ligandi (CD40L) sistemi artmis enflamasyon ve protrombotik yatkinlik sebebiyle aterosklerozla yakin iliskili gibi gorunmektedir.
We report significant increments of surface markers that mediate antigen presentation, that is, CD40 and CD80 at lags 2 and 3, and CD86, HLA-DR, and IgE processing, that is, CD23, at lag 4.
Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study.
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.
Adiponectin, soluble CD40 ligand, IL-18 and MMP-9 are additional biomarkers that have emerged in the search for predictors of a primary adverse cardiovascular event based on clinical data supported by broad experimental evidence.
It seems that targeting CD40 has a double benefit by both killing cells and activating the body's immune system.
Kirin has been creating and developing fully human antibody drugs using its unique TCMouse(TM) Technology Platform, one of which is the CD40 antagonistic mAb.
A EUROPEAN Union (EU) research project is targeting a receptor molecule protein called CD40 commonly found on cancerous cells, in developing a drug stimulating immune systems into attacking tumours.
Further, the center has revealed that BANK regulates the B cell activity by the intermediary of CD40, a kind of intercellular adhesion molecule.
This is the company's third clinical indication for SGN-40, a humanized monoclonal antibody that targets the CD40 antigen.