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CD4 cell count

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CD4 cell count,
a measure of the number of "helper" T cells that carry the CD4 glycoprotein on their cell surface and that help B cells produce certain antibodies. The human immunodeficiency virus (HIV) binds to CD4 and kills T cells bearing this glycoprotein. Thus, the CD4 cell count is an indicator of the progress of an HIV infection and helps measure the effectiveness of anti-HIV drugs. CD4 T cells mainly produce interleukin 2, an autocrine and paracrine T cell growth factor; preactivated or memory CD4 T cells secrete a much larger array of lymphokines on restimulation. See also CD4, CD8 cell, human immunodeficiency virus, T cell.


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Eligibility for antiretroviral treatment is based upon a CD4 cell count <200 cells/ [mm.
The study divided the participants into three groups based on their CD4 cell counts (0-200, 201-350, >350 cells/[mm.
In all these studies, either the number of cases was small or HIV-1 testing was not performed, and CD4 cell count was not routinely done.
 
 
 
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