CD4 cell count

CD4 cell count

a measure of the number of "helper" T cells that carry the CD4 glycoprotein on their cell surface and that help B cells produce certain antibodies. The human immunodeficiency virus (HIV) binds to CD4 and kills T cells bearing this glycoprotein. Thus, the CD4 cell count is an indicator of the progress of an HIV infection and helps measure the effectiveness of anti-HIV drugs. CD4 T cells mainly produce interleukin 2, an autocrine and paracrine T cell growth factor; preactivated or memory CD4 T cells secrete a much larger array of lymphokines on restimulation. See also CD4, CD8 cell, human immunodeficiency virus, T cell.
References in periodicals archive ?
Changes in initial CD4 cell count were examined in four separate time periods: 1985-1990; 1991-1995; 1996-2001; and 2002-2007.
The findings, presented last week at the Sixteenth Conference on Retroviruses and Opportunistic Infections in Montreal, are likely to strengthen the case for a stronger global recommendation that people with HIV should start treatment when the CD4 cell count falls below 350 cells/[mm.
SEATTLE -- Initiating highly active antiretroviral therapy when the patient still has a CD4 cell count between 351 and 500 cells/ [micro]L may be associated with less mortality than waiting until the CD4 count drops below 350 cells/ [micro]L, as is often the standard practice, Dr.
Median baseline viral load was approximately 40 000 copies/ml and the median CD4 cell count was 472 cells/ [mm.
Complete CD4 cell count data for up to 96 weeks following virologic failure was available for 134 patients.
The investigators suggest that better cancer prevention, monitoring and care could help reduce the number of deaths caused by malignancies in patients with HIV, and also stress the importance of keeping the CD4 cell count of HIV-positive individuals above 250 cells/[mm.
And CD4 cell count years above 1600 lowered chances of virus-related cancer 70%.
We sought to evaluate whether insurance was a barrier for patients to enter care for HIV infection by comparing the CD4 cell count levels and HIV viral loads at the time of entry into medical care to three different types of infectious disease practices.
A CD4 cell count below 500 is considered a sign of a weakened immune system, as it indicates lower numbers of white blood cells that fight infections and inflammation.
Some studies have also shown that people treated with AZT have smaller increases in CD4 cell count compared with individuals taking alternative NRTIs.
In addition, we excluded patients who did not have current clinical status available, which was assessed using a patient's most recent viral load and CD4 cell count in the 6 months before the interview date.
Two cases of HSIL+ were observed during the 5 years of observation, 1 among the HIV-uninfected women and 1 among the HIV-infected women with a CD4 cell count of 500 cells/uL or greater.