Human immunodeficiency virus (HIV) has a strong tropism for lymphoid tissues, particularly CD4+ T lymphocytes
, monocytes, and dendritic cells.
The evaluation of CD4+ T lymphocytes in 76 blood samples from healthy volunteers (n = 12) and HIV-1-infected patients (n = 64) showed an [r.
6] cells/L whole blood for CD4+ T lymphocytes and 15 x [10.
HIV targets and destroys CD4+ T lymphocytes
, the key regulatory cells of the immune system gradually leaving the body defenseless against foreign invaders.
CytoDyn's CRO, will present Phase I/II data demonstrating the antiviral effects and absence of liver toxicity in individuals who have failed Highly Active Antiretroviral Therapy (HAART) after Cytolin(R) was used to protect CD4+ T lymphocytes
from the anti-self, anti-CD4 cytotoxic T lymphocytes that proliferate uniquely in humans infected with HIV.
Another mechanism involved is the autophagy, wherein bystander CD4+ T lymphocytes come in contact of HIV env complexes with CXCR4, leading to apoptotic cell death contributing to immunodeficiency (5).
Effect of HIV-1 infection on apoptosis of CD4+ T lymphocytes mediated by Fas.
The CD4+ T lymphocytes were decreased in disease survivors.
In another study the reference ranges of CD4+ T lymphocyte subsets obtained in an Afro-Caribbean population were compared with those published by the WHO and CDC and no significant differences were observed in any of the lymphocyte subsets indicating that the available information can still be used in that population (74).
Quantitation of CD38 activation antigen expression on CD8+ T cells in HIV-1 infection using CD4 expression on CD4+ T lymphocytes
as a biological calibrator.
London, Jan 13 (ANI): In a new study, scientists have uncovered the mechanism behind the prevention of the regeneration of CD4+ T lymphocytes, which are white cells that are required for the proper functioning of the immune system.
By acting on this regulation loop, we can create a homeostatic production of CD4+ T lymphocytes that will allow the immune system to regenerate," Nature quoted Guimond, as saying.