Positive effects of combined antiretroviral therapy on CD4+ T cell
homeostasis and function in advanced HIV disease.
CD127 and CD25 Expression defines CD4+ T cell
subsets that are differentially depleted during HIV infection.
Comparison of capillary based micro-flurometric assay for CD4+ T cell
count estimation with dual platform Flow cytometry.
Regulation of Virus-Specific CD4+ T cell
function by multiple costimulatory receptors during chronic HIV infection.
The CD4+ T cell
count estimation became an important parameter for monitoring immune deficiency after the discovery of the acquired immune deficiency syndrome (AIDS).
Consequently, T cell activation and turnover correlate well with disease progression [11,12] and the rate of CD4+ T cell
In all, these data suggest that the direct consequences of high level virus replication alone cannot account for the progressive CD4+ T cell
depletion leading to AIDS, and that active antiviral cellular immune responses may not always be beneficial.
Vigorous HIV-1-specific CD4+ T cell
responses associated with control of viremia.
Finally, the CD4+ T cell
counts determined by flow cytometry and Capcellia on blood samples from 21 HIV-1-infected patients receiving antiretroviral treatment (zidovudine + didanosine) over an 18-week period were similar.
The strength of the recommendation to treat asymptomatic patients should be based on the willingness and readiness of the individual to begin therapy; the degree of existing immunodeficiency as determined by the CD4+ T cell
count; the risk of disease progression as determined by the CD4+ T cell
count and level of plasma HIV RNA; the potential benefits and risks of initiating therapy in asymptomatic individuals; and the likelihood, after counseling and education, of adherence to the prescribed treatment regimen.
Sustained CD4+ T cell
response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.