Comparison of capillary based micro-flurometric assay for CD4+ T cell
count estimation with dual platform Flow cytometry.
The CD4+ T cell
count estimation became an important parameter for monitoring immune deficiency after the discovery of the acquired immune deficiency syndrome (AIDS).
Consequently, T cell activation and turnover correlate well with disease progression [11,12] and the rate of CD4+ T cell
In all, these data suggest that the direct consequences of high level virus replication alone cannot account for the progressive CD4+ T cell
depletion leading to AIDS, and that active antiviral cellular immune responses may not always be beneficial.
Vigorous HIV-1-specific CD4+ T cell
responses associated with control of viremia.
Finally, the CD4+ T cell
counts determined by flow cytometry and Capcellia on blood samples from 21 HIV-1-infected patients receiving antiretroviral treatment (zidovudine + didanosine) over an 18-week period were similar.
The repeated treatment cycles of CYT107 in this study mimic the way the product will be used in the clinical setting and should trigger an improved and more prolonged immune reconstitution, a stabilization of patient CD4+ T cell
counts above 500/oL, and a decrease of the markers of activation/inflammation," said Michel Morre, DVM, President and CEO of Cytheris.
The unprotected animals had weak CTL response, rapidly falling T-cell counts, and no virus-specific CD4+ T cell
Sustained CD4+ T cell
response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.
The source of this rebounding virus could not be identified and the authors conclude "latent HIV in the resting CD4+ T cell
compartment is a potentially important source of re-emerging virus, [but] is not the sole and often not the major source of viral rebound after discontinuation of therapy.
The primary endpoint was to determine whether the LHRH agonist could induce renewed thymic function and output of new naive CD4+ T cells
(which are required for all immune responses), compared to similar patients not receiving the LHRH.
REMUNE(R)'s effect on immune reconstitution as further evidenced by an augmented serum concentration of IL-7 and increases in naive CD4+ T cells
suggests a possible mode of action via stimulation of thymus function.