CD39

CD39

a transmembrane protein present on macrophages, dendritic cells, and activated lymphoid cells that facilitates B-cell adhesion.
References in periodicals archive ?
The company has built a pipeline of immune checkpoint modulators for targets including PD-1, TIM-3, CD39, and others.
The proinflammatory signaling of extracellular ATP is terminated by nucleotidases active in the interstitial fluid and the membrane-bound ectonucleotidases, CD39 and CD73 (Fig.
The performances of activated microglia include: (1) the alteration of cell morphology from the dendritic appearance to ameboid;[sup][24] (2) The increased expression of surface antigens such as CD14, CD36, CD39, CD45, CD47, and CD54;[sup][25],[26] and (3) The accompanied up-regulation of IL-1[sz], TNF-a, and iNOS.
CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism.
Reduced ROS production in association with decreased levels of JNK and NF-[kappa]B phosphorylation has an impact on both IFN-[gamma] and CD39 expression of [CD8.
5: Las CD39, son las responsables de las actividades enzimaticas extracelulares (ecto-ATPasa), regulan las respuestas inflamatorias y reacciones inmunes mediadas por nucleotidos.
2005) sobre la asociacion del haplotipo del gen [beta] globina a la mutacion CD39 en la poblacion de Corcega se encontro a esta mutacion asociada al haplotipo II en un 18% y al haplotipo I en un 2,3%.
CD38 belongs to an increasingly recognised large number of lymphocyte ecto-enzymes (CD157, CD39 and CD73), which are involved in adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD) metabolism.
Brigham and Women's Hospital, Harvard Medical School CD39 modulates NKT cell-induced oxygen toxicity in the lung
Una vez establecido el contacto, las Tregs pueden destruir las celulas respondedoras incrementando el AMPc intracelular, lo que conduce a la inhibicion de la produccion de IL-2 y de la proliferacion celular (57); generando adenosina intracelular dependiente de CD39 y CD73 (58).
Esto indica una subestimacion del problema y las ventajas de la utilizacion del metodo de HPLC-CE, el cual tambien permitio la clasificacion, de acuerdo a los niveles de Hb A, de los pacientes doble heterocigoto Hb S-[beta] Tal, demostrandose que el mayor numero de casos eran Hb S [beta]o Tal, en concordancia con el hallazgo que la mutacion supresora CD39 es la causa mas frecuente de [beta] talasemia en la poblacion venezolana (Bravo et al.
The detection of the CD39 mutation required the most stringent conditions to differentiate between normal and heterozygous samples, so the conditions selected for this mutation were subsequently applied to the differentiation of normal, mutant, and heterozygous samples for all the other mutations.