CD36


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CD36

a transmembrane protein present on monocytes, platelets, megakaryocytes, the umbilical vein, small-vessel endothelium, reticulocytes, and mammary epithelium that may be involved in signal transduction; expressed in myeloproliferative disorders.

CD36

A gene on chromosome 7q11.2 that encodes the fourth major platelet surface glycoprotein, which is a receptor for thrombospondin. It is acts as a cell adhesion molecule, binding to collagen, thrombospondin, anionic phospholipids, oxidised LDL, long-chain fatty acids and Plasmodium falciparum-parasitised erythrocytes.
 
Molecular pathology
Defects in CD36 cause platelet glycoprotein deficiency; genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7.
References in periodicals archive ?
Transcription analysis of 44 CD genes was also carried out, indicating 24 CD genes (CD3E, CD244, CD69, CD247, CD40L, CD38, CD5L, CD44, CD5, CD83, CD163L1, CD36, CD14, CD28, CD200R1A, CD40, CD59, CD200, CD4, CD2, CD72, CD180, CD79B, and CD93) to be markedly increased by 2.
oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4.
The LBE treated cells showed a specific increase in expression of PPAR target gene expression, including fatty acid binding protein 4, fatty acid transport protein 4, CD36 molecule, pyruvate dehydrogenase kinase 4, liver X receptor alpha and lipogenic stearoyl-CoA desaturase.
Characterization of peroxynitriteoxidized low density lipoprotein binding to human CD36.
There are many different DBL-[gamma] domains binding to CSA and several CIDR-[alpha] type domains which bind to CD36.
CD36 ELISA Assay: An ELISA assay specific to mouse CD36 fatty acid transport protein was purchased from Abcam (Cambridge, MA) and performed in accordance with manufacturer's protocols.
CD36 is a membrane receptor associated with uptake of oxidized low-density lipoproteins (Endemann et al.
CD36 is a busy molecule, regularly making contact with a wide variety of proteins in the extracellular matrix and on neighboring cells.
Instead, a receptor called CD36 present on macrophages draws the soluble forms of these particles inside the cell where they are transformed into substances that trigger an inflammatory response.
Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression.
TSP-1 participates in inhibition of angiogenesis which is mediated by its interactions with CD36, integrins receptors in endothelial cells [30].