ERBB2

(redirected from CD340)

ERBB2

A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and enhancing kinase-mediated activation of downstream signalling pathways (e.g., those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase).

Molecular pathology
ERBB2 amplification and overexpression commonly occurs in breast and ovarian cancers.
References in periodicals archive ?
Human epidermal growth factor receptor 2 (Her2/neu, also referred to as ERBB2, CD340, or p185, encoded by gene ERBB2) is a member of the epidermal growth factor receptor family (ErbB protein family).
Phase I - To construct the initial data pool, the keywords "breast cancer, invasive ductal carcinoma, invasive lobular carcinoma, infiltrating ductal carcinoma, infiltrating lobular carcinoma, DCIS,ductal carcinoma, LCIS, lobular carcinoma, her2neu, her2/neu, ErbB-2, CD340, BRCA, triple negative carcinoma and basaloid cancer" were used to search titles, abstracts, and keywords of original articles, reviews, and proceedings papers published in the SciVerse Scopus™ database (http://www.