CD30


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CD30

a type I transmembrane protein present on activated T and B cells that may play a role in cell activation and/or differentiation; expressed in Hodgkin disease, some T-cell lymphomas, and anaplastic large cell lymphomas.
References in periodicals archive ?
ADCETRIS (brentuximab vedotin) is an antibody-drug conjugate (ADC) directed to CD30, a defining marker of classical Hodgkin lymphoma.
Neoplastic lymphoid cells were diffusely immunohistochemically positive for CD30 and focally positive for CD3 (a T-cell marker) and epithelial membrane antigen.
The distinctive Reed-Sternberg and Hodgkin cells are nearly always CD30 positive.
To determinate, relationship between variations of CD30 marker expressed in cancerous cells and clonality rates, the Pearson's chi-square ([chi square] test) and Fisher's exact tests were performed.
However, given unusual cytologic features of the tumor, further immunohistochemical stains were performed, which showed the tumor to be strongly positive for CD30 (Figure 3, C), CD4 (Figure 3, D), and CD43, and negative for anaplastic lymphoma kinase, most suggestive of cALCL.
Immunohistokimyasal incelemede lenfosit lerde CD20 ve CD3 antijenlerinin pozitif oldugu ve seyrek olarak CD30 ile pozitif reaktivite veren aktive lenfositler goruldu.
The CD30 molecule, a member of the TNF superfamily of membrane cytokine receptors, is expressed by activated CD4+T cells predominantly producing Th2 type cytokines in vitro (8).
The longest paper in this collection is an Italian study on whether the CD30 co-stimulator molecule is the unknown molecule involved in the cell contact-dependent suppression of T regulatory cells by regulatory dendritic cells.
All versions will come with a comprehensive equipment list including remote central locking, a CD30 stereo-CD player, side-protection mouldings, under seat storage areas, a driver's airbag and a full-sized spare wheel.
In a study involving nearly 4,000 patients published last year in the Journal of the American Society of Nephrology, Professor Gerhard Opelz, Caner Suesal, MD, and colleagues of the Heidelberg University Hospital found that the higher the soluble CD30 level, the more likely a rejection reaction.
The CD30 antigen is known to be expressed on the Reed-Sternberg cells of HL and on sALCL, an aggressive type of T-cell non-Hodgkin lymphoma.