CD3

(redirected from CD3 zeta)

CD3

a type I transmembrane protein found on T cells that forms the signal transduction unit for the T cell; expressed in patients with T-cell lymphomas.

CD3

T3 A complex of 5 invariable polypeptide chains, which are part of a larger complex that includes the T cell receptor; CD3 is 'pan-T' cell antigen–ie, present on most mature T cells–60-85% of peripheral T cells, 20-85% of thymocytes. See Pan-T cell markers.

CD2

cluster of differentiation or cell differentiation glycoproteins.

CD antigen
a group of cell surface molecules which act as markers on T lymphocytes.
CD3
found on T helper (Th) and T cytotoxic (Tc) lymphocytes; associated with signal transduction.
CD4
found on T helper lymphocytes; an adhesion molecule that binds to class II MHC molecules.
CD8
found on T cytotoxic and variably on NK lymphocytes; an adhesion molecule that binds to class I MHC molecules.
References in periodicals archive ?
Among the findings presented was that treatment with a combination of Ceplene and IL-2 significantly increased the expression of CD3 zeta in T cells and Natural Killer (NK) cells, white blood cells with anti-cancer properties.
The CD3 zeta molecule is believed to be a surrogate indicator of the activity of two classes of key white blood cells, natural killer (NK) and T cells (CD4+ and CD8+), which are further believed to have protective effects against leukemic cells.
This recent data regarding CD3 zeta expression may explain the beneficial results that have been observed in AML patients treated with Maxamine and IL-2 to date," said Mats Brune, M.
The deficiency of CD3 zeta may explain why NK cells and T cells are frequently non-functional and cannot exert their protective effects in cancer patients.
As reported by the research team at the Karolinska Hospital and presented at the European Hematology Meeting, the purpose of the study was to determine the effect of Maxamine and IL-2 on the expression of CD3 zeta in white blood cells of AML patients.
The CD3 zeta expression on NK cells and T cells was reduced
In the AML patients with reduced CD3 zeta, the CD3 zeta