CD25

CD25

a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.

Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.

Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.
References in periodicals archive ?
Soluble CD25 level [greater than or equal to] 2400 U/mL###Not checked
Flow cytometry of peripheral blood revealed an expression of CD3, CD4, CD5, TCR[alpha][beta] and CD2 with co-expression of CD25.
Elevated soluble CD25 and IL-2 receptor markers are HLH-specific markers.
Part 3 of method validation consists of the validation of the FACS method for analysis of CD4 Thl/Th2 subset (CD3, CD4, IFN-Gamma, IL-4) and T Regulatory (CD3, CD4, CD25, FoxP3, CD127) response.
While the precise mechanism of action of ZINBRYTA is unknown, it is thought to work differently from other disease-modifying therapies by binding to CD25, a subunit of the interleukin-2 (IL-2) receptor found on activated lymphocytes, cells believed to underlie the biology of MS.
As well as CD25, other markers such as GITR, CTLA-4, CD 103 and OX-40 are overexpressed on T reg cells but their expression is not as specific as CD25 on regulatory T cells (2).
Estos inducen la conversion de un mayor numero de celulas al fenotipo CD25 + Foxp3 que los LB foliculares del mismo organo (28).
Elevated soluble CD25 (soluble IL-2 receptor alpha) two standard deviations above age - adjusted laboratory - specific norms.
4) Another report from China described a case of suspected HLH with low natural killer cell activity and high CD25 levels which preceded the histological diagnosis of MBL.
Staining of surface (CD3, CD4, CD25, CCR4, CCR10, neuropilin, MHC class II, and CD11c) and intracellular (Foxp3) antigens was performed as previously described [9].
MGEB inhibited Con A-induced proliferation and the expression levels of cell surface molecules CD69 and CD25 of T cells in vitro.