CD25


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CD25

a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.

Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.

Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.
References in periodicals archive ?
Neoplastic mast cells, in addition to tryptase and CD117, show aberrant expression of CD2 and/or CD25.
We could not study the NK cell activity or levels of CD25, but our case fulfilled the other criteria.
Zinc-Dependent Regulation of the Cell Cycle Regulator CD25 as Potential Anti-Cancer Target"; Dr.
Upregulation of FoxP3 and CD25 without conferment of suppressive function has been demonstrated in CD4+ T cells following cellular activation [47,48], while reduced expression of CD127 is a feature of activated CD4+ T cells in patients with progressive HIV disease [32].
Although stimulation by MSSA caused an increase in CD25 expression after 24 h, the increase was found to be lower than the one caused by MRSA stimulation.
In a Phase II trial involving 230 RRMS patients treated with interferon beta, Xavier Montalban reported that adding daclizumab, a monoclonal antibody targeting CD25 (IL2Ra), reduced by 72% the number of new or enlarging T2 lesions in the high-dose group of patients compared with those receiving placebo.
The product is a fully human monoclonal antibody targeting the TAC antigen - also known as CD25, or the interleukin-2 receptor alpha subunit (IL-2Ra) - which is overexpressed by activated T-cells.
CD25 bright CD4* regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease.
Calcineurin also directly activates the lymphocytes by upregulating the expression of T-cell surface receptors, including the IL-2 receptor [alpha] chain CD25 and the transferin receptor CD71.
Blasts of myeloid leukemia with basophilic differentiation may not exhibit reactivity for myeloperoxidase and express myeloid markers such as CD33, CD13 and CD117 along with CD9 and CD25, which are usually associated with basophilic lineage of cells [3,4].
2] 4 [+ or -] 7 pg/mL IFN-[Gamma] 383 [+ or -] 859 ng/mL sICAM-1 263 [+ or -] 173 pg/mL TNF-[Alpha] 12 [+ or -] 55 pg/mL CD3 1,380 [+ or -] 432 [micro]L CD4 837 [+ or -] 297/[micro]L CD8 451 [+ or -] 176/[micro]L OK-DR 317 [+ or -] 127/[micro]L CD25 119 [+ or -] 57/[micro]L CD16 183 [+ or -] 110/[micro]L CD19 228 [+ or -] 118/[micro]L CD11b 216 [+ or -] 176/[micro]L CD8+/CD56+ NK subset 134 [+ or -] 113/[micro]L Abbreviations: IFN, interferon; IL, interleukin; sICAM-1, soluble intercellular adhesion molecule 1; sIL, soluble IL-1 receptor antagonist; TGF-[[Beta].
Apoptosis, cell viability, cell number and CD25 expression on T-cells were measured by flow cytometry.