ALK

(redirected from CD246)
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ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
CD3, CD4, CD9, CD11, CD19, CD20, CD22, CD26, CD27, CD28, CD29, CD33, CD37, CD40, CD44, CD45, CD47, CD52u CD55, CD56, CD66, CD70, CD74, CD80, CD95, CD98, CD100, CD117, CD135, CD137, CD152, CD200, CD223, CD227, CD246, CD248, CD274, CD276, CD279
CD246 anti-ALK protein mouse monoclonal antibody (mAB) and anti-nucleophosmin mouse mAB, were from Dako Cytomation (Glostrup, Denmark), PDGF-R[beta] rabbit mAB and caspase 3 polyclonal antibody (pAB), histone H3 rabbit mAb and phospho-histone H3 rabbit pAB from Cell Signaling (Cambridge, UK).
However, IHC studies using the anti-ALK1 antibody typically used for anaplastic large celll ymphoma (mousemonoclonalanti-human CD246, clone ALK1) have been disappointing, likely due to the low expression level of the fusion protein in ALKrearranged lung adenocarcinomas in comparison to anaplastic large cell lymphoma.