For example, leaving a diffuse small lymphoid cell infiltrate categorised as small B cell lymphoma without investigating CD5, CD23
, cyclin D1, and Ki-67 expression to differentiate chronic lymphocytic leukemia/ small lymphocytic lymphoma, mantle cell lymphoma or marginal zone lymphoma is incorrect as these diseases are often treated with different protocols.
We report significant increments of surface markers that mediate antigen presentation, that is, CD40 and CD80 at lags 2 and 3, and CD86, HLA-DR, and IgE processing, that is, CD23
, at lag 4.
Mantle cell lymphoma has a phenotype closely related to CLL but tends not to express CD23
, and has moderate expression of surface immunoglobulin.
The above results suggest that RG and FRG possibly inhibited the IgE-Ag transport from the lumen of gut to the mucosa through inhibition of CD23
expression, following a reduction of IL-4 expression in the intestinal mucosa.
Immunohistochemical stains were positive for CD21, CD23
, and CD35 and negative for CDlp, S-100, CD20, CD3, CD31, CD34, and cytokeratin.
A mite subversive: cleavage of CD23
and CD25 by Der p 1 enhances ellergenicity.
Bone marrow biopsy revealed infiltration with [kappa]-restricted lymphocytes positive for CD5, CD19, CD20 (dim) and CD23
65 per 100 000 males and females, respectively) (3) in which the abnormal cells characteristically express CD5 and CD23
and involve the blood, bone marrow, and lymph nodes.
Interestingly, only 3 of the 33 patients in the present study had typical mature B-cell phenotype-positive CD19, CD20, CD10, surface IgM, and CD 79a, and negative CD5, CD23
, and TdT.
MCL is characterized by strong expression of cyclin D-1, as well as CD5 and CD20 positivity; CD23
negativity helps distinguish it from chronic lymphocytic leukemia and small lymphocytic lymphoma.
Immunophenotyping of these tumor cells reveals that they express surface immunoglobulins and B-cell antigens but lack CD5, CD10, and CD23
Staining with CD5, CD10, and CD23
is usually absent.