Flow cytometry showed a 96% variable size, clonal B cell population expressing CD10, CD11c, CD19, CD20, CD22
, CD45, CD52, CD103, CD123, BCL2, and Kappa.
has entered into an agreement to obtain a license for the company's CAR-T cell product candidate targeting CD22
, a protein expressed on most B cell leukemias and lymphomas.
CD3, CD4, CD9, CD11, CD19, CD20, CD22
, CD26, CD27, CD28, CD29, CD33, CD37, CD40, CD44, CD45, CD47, CD52u CD55, CD56, CD66, CD70, CD74, CD80, CD95, CD98, CD100, CD117, CD135, CD137, CD152, CD200, CD22
7, CD246, CD248, CD274, CD276, CD279
6,17,18) EBV-positive DLBCL of the elderly will express at least some Bcell markers (CD19, CD20, CD22
, CD79a, PAX-5), as well as IRF4/MUM-1.
In addition to targeting CD20, we are studying a humanized antibody (less mouse protein) against CD22
, another marker for NHL, labeled with [sup.
III] specific A kinase (PRKA) anchor AKAP5 Signal transduction protein 5 Ataxin 1 ATXN1 RNA binding CD22
Cell adhesion Connective tissue CTGF Regulation of cell growth factor growth, cell adhesion RNA, U70 small nucleolar RNU70 Unknown Integrin beta 1 binding ITGB1BP1 Cell adhesion protein 1 E2F transcription E2F1 [G.
epratuzumab, AMG CD22
is commonly expressed by B-cell 412) malignant cells.
In a related development, the company announced that near-term clinical development plans now include the further evaluation of two proprietary cancer therapeutics, its humanized CD22
antibody (IMMU-103) and its CD20 antibody (IMMU-106), in each case for patients with certain autoimmune diseases.
He and his colleagues designed BL22 as a so-called fusion protein that combines a toxin with an antibody that attaches to the CD22
Hairy cells will often demonstrate bright CD22
and CD11c co-expression and segregate out as a distinct population on two-color flow cytometric analysis.
New (Research Collaboration) -- Inhibition of B Cell Activation and Plasma Cell Differentiation by Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22
, CD25, CD30, CD33 and others are being investigated.