TEK

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TEK

A gene on chromosome 9p21 that encodes a transmembrane tyrosine protein kinase that forms a heterodimer with TIE1, modulating its activity. TEK acts as a receptor for ANGPT1, ANGPT2 and ANGPT4, regulating angiogenesis; endothelial cell survival, proliferation, migration, adhesion and cell spreading; reorganisation of the actin cytoskeleton; and, depending on context, maintenance of vascular quiescence. TEK has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels into interstitial tissue. It is required for normal angiogenesis and heart development during embryogenesis, and it is required for postnatal haematopoiesis.