CD20


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CD20

a type III transmembrane protein found on B cells that forms a calcium channel in the cell wall allowing for the influx of calcium required for cell activation; expressed in B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia.

KRT20

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that is a major cellular protein of mature enterocytes and goblet cells, and is specifically expressed in gastric and intestinal mucosa.

CD20

An antigenic protein found only on the surface of B lymphocytes. It can be used to identify and separate those cells from others and can be exploited as a target for monoclonal antibody therapy.
References in periodicals archive ?
Poster 531 - Statins Impair Antitumor Effects of CD20 mAb by Inducing Conformational Changes of CD20
GlaxoSmithKline (GSK) and Genmab A/S (CSE: GEN) today announced a worldwide agreement to co-develop and commercialize HuMax-CD20(TM) (ofatumumab), a fully human monoclonal antibody in late stage development for CD20 positive B-cell chronic lymphocytic leukemia (B-CLL) and follicular non-Hodgkin's lymphoma (NHL) and in Phase II for rheumatoid arthritis (RA).
Rituxan is a therapeutic antibody that binds to a particular protein, the CD20 antigen found on the surface of malignant cells as well as normal B-cells.
Effectively Killed by Ofatumumab-Induced Complement-Mediated Cytoxicity Poster 531 - Statins Impair Antitumor Effects of CD20 mAb by Inducing Conformational Changes of CD20
GTC also has a monoclonal antibody portfolio that includes a monoclonal antibody to CD20 and a monoclonal antibody to CD137.
com/research/6e6e9b/competitor_analysi) has announced the addition of the "Competitor Analysis: CD20 Antibodies" report to their offering.
19 /PRNewswire-FirstCall/ -- GlaxoSmithKline (GSK) and Genmab A/S today announced a worldwide agreement to co-develop and commercialize HuMax- CD20(TM) (ofatumumab), a fully human monoclonal antibody in late stage development for CD20 positive B-cell chronic lymphocytic leukemia (B-CLL) and follicular non-Hodgkin's lymphoma (NHL) and in Phase II for rheumatoid arthritis (RA).
HuMax-CD20 is a human antibody which is effective at binding to the CD20 molecule on B-cells.
The development and commercial potential of GA101 is subject to a number of risks and uncertainties, including the potential safety and efficacy profile of GA101 relative to other related CD20 antibodies, the projected timeline for completion of the ongoing Phase I/II study; the projected impact of GA101 on the Company's quarterly operating expenses; and other statements that are other than statements of historical facts.
These data strongly support further development of HuMax- CD20 in CLL," said Lisa N.
CD20 is not found on stem cells, pro-B cells (B-cell precursors), normal plasma cells, or other normal tissues.
About LFB's anti-CD20 LFB's anti-CD20 antibody (LFB-R603) is a chimeric recombinant monoclonal antibody directed towards the CD20 antigen expressed on the surface of B cells.