CXCR2

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CXCR2

A gene on chromosome 2q35 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which selectively binds IL8, as well as CXCL1, CXCL3, GRO/MGSA and NAP-2. CXCR2 is a potent neutrophil chemotactic factor and mediates neutrophil migration to sites of inflammation; it mediates IL8’s angiogenic effects on intestinal microvascular endothelial cells.