CD163

CD163

A transmembrane protein encoded by CD163 on chromosome 12p13.3, which mediates the endocytosis of haptoglobin-haemoglobin complexes. CD163 belongs to the cysteine-rich scavenger receptor superfamily
Normal expression Highly expressed by tissue macrophages and less so by circulating monocytes. In a soluble form in plasma, it has an anti-inflammatory function.
Abnormal expression Expression is upregulated during inflammation by glucocorticoids, IL-10 and other modulators.

CD163

A cell surface glycoprotein used in immunohistochemistry to identify monocytes and macrophages.
See: cluster of differentiation
References in periodicals archive ?
CD68 and CD163 are consistently positive in macrophages and are negative in carcinoma cells.
When considering the diagnosis of myeloid sarcoma, an appropriate panel of stains includes several immunohistochemical stains and special stains, specifically CD34, CD43, lysozyme, myeloperoxidase, CD68 (monocyte marker), CD163 (monocyte marker), and CD117 (3, 4, 6).
These immunohistochemical studies included reagents specific for CD3, CD11c, CD20, CD33, CD43, CD68, CD117, CD163, lysozyme, and myeloperoxidase.
Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified corollary plaque in HIV-infected patients.
Immunohhistochemical Marker Cell type CD45 CD21 CD23 CD35 SI00 CDla Langerin Fascin LCH LC (+) (-) (-) (-) (+) (+) (+) only + IDC (+) (-) (-) (-) (+) (-) (-) (+) Macrophage or (+) (-) (-) (-) (+/-) (-) (-) (+/-) histiocyte l/DDC (+) (-) (-) (-) (-/+) (-) (-) (+) pDC (-) (-) (-) (-) (-) (-) (-) (-) FDC (-) (+) (+) (+) (+/-) (-) (-) (+) FRC (+) (-) (-) (-) (-) (-) (-) Cell type Clusterin CD68 CD123 CD163 CD4 FXIIIa TCLI LC (-) (+) (-) (-) (+) (-) (-) IDC (-/+) (+/-) (-) (-) (+) (-) y Macrophage or (-) (+) (-) (+) (+) (-) (-) histiocyte l/DDC (-) (+) (-) (-) (+/-) (+) (-) pDC (-) (+) (+.
Free hemoglobin dimers bind to haptoglobin with very high affinity, and these complexes are rapidly removed by a macrophage receptor CD163.
The new study indeed showed that arterial inflammation in the HIV-positive group was correlated with levels of soluble CD163, a marker of monocyte activation.
We tested the regulation of the proinflammatory genes CD14, IL6, IL8, monocyte chemoattractant protein 1 (MCP1), CC12, PAH, and tumor necrosis factor-alpha (TNFa) and the anti-inflammatory genes CD163, interleukin 1 receptor antagonist (ILIra), and IL10, all reported to code for secreted proteins that are up-regulated in obesity (Fain 2010).
The method involves administering an effective amount of a substance which can activate the CD163 hemoglobin scavenger receptor signal transduction pathway.
This was confirmed by the immunohistochemical staining for macrophage marker CD163 (Fig.
CRx-170 did not show a modulation of the inflammatory marker CD163 from the treatment baseline, although nortriptyline clearly did decrease CD163 on its own.
17) The characteristic antigens expressed in HS include CD163, CD68 (Figure 1, B, inset), and lysozyme.