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Blocking the interaction between CD40 and CD154 by anti-CD154 or anti-CD40 antibody has been found to be beneficial in several animal models of autoimmune diseases and transplantation [6,7].
Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failure.
CD40 and the B7 family proteins (CD80, CD86, and others), which are expressed on "antigen presenting cells", bind to CD154 and CD28 or CTLA-4, respectively, ligands which are expressed mainly on responding T cells.
4) They include antibodies against T-cell marker of Tumor Necrosis Factor (TNF) family: CD154 and thrombopoietin (TPO) protein agonists.
Induction of a CD4+CD25+ T cell subset following blockade of CD154 in a Phase I clinical trial in RRMS.
University of California (Oakland, CA) has patented an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor.
Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (DD40-ligand) transgene.
For example, CD154 induces maturation of immune system components called dendritic cells, which in turn stimulate T- and B-cell growth.
Intrahepatic islet cell allografts combined with treatment using a genetically-engineered antibody to CD154, a substance that is a key factor in islet rejection, has resulted in long-term engraftment and insulin-independence in diabetic rhesus monkeys and prompted the Food and Drug Administration to approve a pilot trial in humans.
The risk for throm boembolic disease in lupus anticoagulant patients due to pathways involving P-selectin and CD154.
At the core of this reaction is a molecule called CD154.
Allergen-Specific CD154 and Intracellular Cytokine Expression Is a Sensitive Biomarker of Th1/Th2 Balance Applicable for Measurement of Human T Cell Responses to Therapeutic Interventions - Abstract #3584 Poster Session: B21 - Airway Inflammation: New Information About Mediators and Biomarkers Tuesday, May 19, 2009, 8:15 am - 4:00 pm