CD14


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CD14

a transmembrane protein found on monocytes, macrophages, neutrophils, some B cells, and dendritic cells that is involved in signal transduction leading to oxidative burst and/or synthesis of tumor necrosis factor-α; expressed in some patients with acute nonlymphocytic leukemia and in B-cell chronic lymphocytic leukemia.
References in periodicals archive ?
They found that food allergy patients were nearly four times more likely to have two copies of the T version (TT genotype) of the CD14 promoter.
The cells were washed with PBS and incubated simultaneously with phycoeiythrin (PE)-conjugated anti-human CD1lb or fluorescein isothiocyanate (FITC)-conjugated anti-human CD14 monoclonal antibodies (BD Bioscience in San Jose, CA).
Monocyte numbers were assessed in each specimen by CD14 staining.
Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.
The cells in the gated region were negative for all other antigens tested, including HLA-DR (0%), CD34 (3%), CD13 (3%), CD33 (3%), CD14 (0%), CD2 (3%), CD3 (2%), CD4 (3%), CD5 (1%), CD7 (4%), CD8 (0%), CD10 (0%), CD19 (0%), CD20 (0%), CD22 (0%), CD41 (3%), CD61 (1%), and CD71 (9%).
Lipopolysac-charide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within micro-vessels.
The inflammatory reactions are orchestrated by alveolar macrophages that carry specific endotoxin binding receptors [LPS binding protein, CD14, MD2, toll-like receptor (TLR) 4], which play a crucial role in the activation of these cells and the subsequent inflammatory processes (Gioannini et al.
CD13, CD15, CD33, CD34, and HLA-DR are positive for M2a leukemia, and CD14 is negative for M2a leukemia (9).
TLR4, in a complex with MD2 (myeloid differentiation protein) and CD14 (a 55-kDa protein), binds to the lipopolysaccharides (LPS) of gram-negative bacteria as a ligand, and activates several downstream signaling pathways (Poltorak.
CD14 transfers LPS to the Toll-like receptor-4 (TLR-4) expressed on a variety of cells in the immune system.