IL4R

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IL4R

A gene on chromosome 16p12.1-p11.2 that encodes the alpha chain of the IL4 receptor, a type-I transmembrane protein which can bind IL4 and IL13 to regulate IgE production. ILR4 also binds IL4 to promote differentiation of Th2 cells.

Molecular pathology
Allelic variants in IL4R have been associated with atopy, which is accompanied by allergic rhinitis, sinusitus, asthma and eczema, as well as by Japanese cedar pollinosis.