17] found lower mean CD3+, CD4+, CD18 and CD11a
and CD4+/CD8+ ratio in 20 preterm and term neonates with sepsis, compared with 23 healthy control subjects.
Intravascular large B-cell lymphoma cells have been demonstrated to lack cell surface proteins critical to lymphocyte transvascular migration, including CD29 ([beta]1 integrin) and CD54 (ICAM-1 or CD11a
However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated antigen, or CD11a
expression by CD4 (+) T cells or their physical capacity for migration.
Lenfosit fonksiyonu ile iliskili antijen-1 (LFA-1) yapisindaki CD11a
kismina baglanarak T lenfositlerin, antijen sunan hucreler, vaskuler endotelyal hucreler ve keratinositlerde eksprese edilen interseluler adezyon molekulu-1 (ICAM-1) ile etkilesimini engeller (3,4).
Expression of CD18 was also reduced on PMNs (Figure 2D), and ANOVA indicated significantly increased CD11a
expression on PMNs (exposure-time interaction, p = 0.
Efalizumab, a new humanized monoclonal antibody, targets CD11a
, one of the subunits of LFA-1, and is being used to treat psoriasis.
Efalizumab is a humanized monoclonal IgG1 antibody that binds to CD11a
, the alpha chain of leukocyte function-associated antigen-1 that is expressed on the surface of T cells.
29) In another study, weak immunohistochemistry staining for CD44, leukocytefunction antigen 1, CD11a
, and CD18 in NHL samples all correlated with stage I disease, less frequent hematogenous dissemination, and a more favorable prognosis.
Etki mekanizmasc Efalizumab (Raptiva[R]) humanize IgG1 monoklonal antikoru olup T hucre yuzeyinde bulunan CD11a
molekulune baglanarak onu bloke eder.
antibody has proved effective for psoriasis in clinical trials.
Its proprietary drug candidate Cytolin(R) is a monoclonal antibody that binds to CD11a
, a cellular antigen that is a component of the cellular adhesion molecule LFA-1.
Alefacept LFA-3/IgG fuzyon proteini olup CD2 ye baglanir, efalizumab ise LFA-1 in alt unitesi CD11a
ya baglanarak ASH ve T lenfosit arasindaki iliskiyi bozar, antijen sunumunu yeterli yapamayan ASH T lenfositi tam olarak aktive edemez ve patojenik T lenfositleri cogalamaz.