CD103

CD103

a type I transmembrane protein present on intestinal intraepithelial lymphocytes, some circulating leukocytes, and some T cells that facilitates adhesion to epithelia; expressed in hairy cell leukemia and some B-cell chronic lymphocytic leukemias.
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57) Hairy cell leukemia is positive for all common B-cell antigens (CD19, CD20, CD79a, FMC-7, and PAX5), with characteristic expression of annexin A1 (Figure 7, A), CD11c, CD25, CD103, CD123, DBA-44 (CD72) (Figure 7, B), the Hector Battifora mesothelial epitope-1 (HBME-1), pERK, Tbet, and TRAP58-61 but is typically negative for CD5 and CD10, although 10% to 20% of HCLs are positive for CD10.
44) These Tregs express CD103, CCR4, and CCR5, but the molecular mechanism underlying their migration from the skin to lymph nodes remains unclear.
In all cases, an immunophenotypic analysis was performed by flow cytometry, including CD19, CD5, CD22, CD23, CD38, CD25, CD103, CD11c, FMC7, BCL2, CD10, CD20, and surface immunoglobulins ?
En este sentido se ha demostrado que Leishmania major tiene la capacidad de incrementar la expresion de la integrina CD103 mediado por TGF- P.
Los LT CD8+ que expresan la integrina CD103, cuyo ligando es la cadherina E, migran (exocitosis) hasta la epidermis y permanecen en la placa psoriatica; (3,7,8) producen IFN-[gamma] que es responsable de la persistencia de las lesiones cutaneas.
Biotin-conjugated CD103 antibody was purchased from BioLegend (San Diego, CA).
The immunophenotype differs somewhat from classical HCL in that there is variable expression of CD103 and lack of CD25 [9].
Diagnosis CD5 CD10 CD19 CD20 CD23 SLL/CLL (a) + - + +(w) + Mantle cell lymphoma + - + + - Follicle center lymphoma - + + + -/+ Marginal zone lymphoma - - + + - Hairy cell leukemia - - + + - Diagnosis CD79b FMC-7 CD25 CD11C CD103 SLL/CLL (a) - - -/+ +/_ - Mantle cell lymphoma + + - - - Follicle center lymphoma +/- +/- - - - Marginal zone lymphoma +/- +/- -/+ + - Hairy cell leukemia +/- +/- +/- + + (a) SLL/CLL, small lymphocytic lymphoma/chronic lymphocytic leukemia; +, positive; -, negative; +/-, often positive; -/+, occasionally positive; w, weak expression.
Hairy cells are also characteristically CD11c, CD19, CD20, CD22, CD25, CD103, and variably CD38 positive.
Immunohistochemical testing was performed on paraffin sections using rabbit antibody to CD103 (clone EPR4166, Abcam, Cambridge, Massachusetts) and mouse monoclonal antibody to Pax5 (clone 1EW, Leica Microsystems, Buffalo Grove, Illinois).
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In addition, some antigens, such as CD103 in hairy cell leukemia and enteropathy-associated T-cell lymphoma, can only be detected by flow cytometry because of the lack of effective antibodies that work on fixed tissue in immunohistochemistry.