CCR8


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CCR8

A gene on chromosome 3p22 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR8 is preferentially expresses in the thymus; its ligands include thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 (MIP-1) beta. CCR8 is thought to have a central role in regulating monocyte chemotaxis and thymic cell apoptosis, and it may also contribute to positioning of activated T cells within antigenic challenge sites and specialised areas of lymphoid tissues.
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As a ligand for CCR4 and CCR8, which are expressed by T cells, it might also be involved in the specific interaction of DCs with T cells.
Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
4] Human genes: RPLPO, ribosomal protein, large, P0; PPIA, peptidylprolyl isomerase A (cyclophilin A); TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A; CCL11, CCL17, CCL19, CCL22, CCL3, CCL4, chemokine (C-C motif) ligand 11, 17, 19, 22, 3, and 4; CL5 chemokine (C-C motif) ligand 5; CCR1, CCR7, CCR8, chemokine (C-C motif) receptor 1, 7, and 8; CD86, CD86 molecule; CXCL12, chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXCL2, chemokine (C-X-C motif) ligand 2; CXCR4, chemokine (C-X-C motif) receptor 4; L128, interleukin 12B (natural killer cell-stimulating factor 2, cytotoxic lymphocyte maturation factor 2, p40); IL15, IL4, IL8, interleukin 15, 4, and 8; HPRT1, hypoxanthine phosphoribosyltransferase 1; PGK1, phosphoglycerate kinase 1.