CCR7


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CCR7

A gene on chromosome 17q12-q21.2 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR7 is expressed in various lymphoid tissues and activates B and T lymphocytes. It controls migration of memory T cells to inflamed tissues and stimulates dendritic cell maturation.
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The upregulation of CCR7 upon maturation of DCs was shown in 1998 (12).
Upregulation of CCR7 and CXCR4 was also found by others.
DINP also significantly increased the expression of the chemokine receptors CCR7 (Figure 3C; 100 [micro]M DINP, p < 0.
CCR7 and CXCR4 are chemokine receptors for regulating dendritic cell function and migration into draining lymph nodes (Kahashima et al.
5] Human genes: CD2, CD2 molecule; CD3E, CD3e molecule, e (CD3-TCR complex); LCK, lymphocyte-specific protein tyrosine kinase; GZMA, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); CD28, CD28 molecule; MNDA, myeloid cell nuclear differentiation antigen; LYN, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; MYC, v-myc myelocytomatosis viral oncogene homolog (avian); BTG1, B-cell translocation gene 1, anti-proliferafive; CD79A, CD79a molecule, immunoglobulin-associated a; FAIM3, Fas apoptotic inhibitory molecule 3; CCR7, chemokine (C-C mofif) receptor 7; CD48, CD48 molecule; HLA-DRA, major histocompatibility complex, class II, DR a; FCER2, Fc fragment of IgE, low affinity II, receptor for (CD23); CD52, CD52 molecule.
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Two weeks of treatment with Leukine resulted in a significant increase in the proportion of total mature dendritic cells as defined by expression of CD86, CD83, CCR7 and CD40 molecules.
Expression Pattern of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck Identifies a Novel Metastatic Phenotype," citing Greenlee, R.