CCR6


Also found in: Acronyms.

CCR6

A gene on chromosome 6q27 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR6 is preferentially expressed by immature dendritic cells and memory T cells, and may be important for B-lineage maturation and antigen-driven B-cell differentiation; it may regulate migration and recruitment of dentritic and T cells during inflammation. Its ligand is macrophage inflammatory protein 3 alpha (MIP-3 alpha).
References in periodicals archive ?
The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut.
2010) A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation.
45) They showed that 1 [micro]g/ml of hBD-2 contributes to the chemoattraction of immature dendritic cells through the CCR6 receptor.
48) Because macrophages have no CCR6 receptors, the identification of other receptors for [beta]-defensins had been pursued.
1999) [beta]-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.