CCR5

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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
Additional candidates have been highlighted in the literature, including the leukotoxin LukED which targets the human CCR5 receptor (Alonzo, 2013).
LPS induces CCR5 receptor expression via the EGFR, COX-2 and ERK1/2 pathways
Altering CCR5 receptor will help disable the virus' ability to use T-cells to infect humans.
SCH D: Antiviral activity of a CCR5 receptor antagonist.
Rockville, MD) announced that Human Genome Sciences has acquired an exclusive worldwide license from Abgenix to develop and commercialize a fully human monoclonal antibody to the CCR5 receptor.
Usually, the virus goes for the so-called CCR5 receptor, but some HIV strains latch onto CXCR4.
In laboratory studies, PRO 140 has demonstrated potent, broad-spectrum antiviral activity against approximately 100 genetically diverse HIV strains, isolated directly from infected individuals, which use the CCR5 receptor.
Moreover, these trials suggested that PRO 140 does not affect the normal function of the CCR5 receptor.
The team showed that oncogenes turn on the CCR5 receptor in normal breast cells as they became transformed into cancer cells.
That research has suggested that the connection might be through the CCR5 receptor, the major coreceptor of HIV on CD4 cells.
But the beta Chemokines only block some HIV viruses, those that use the CCR5 receptor on the CD4 cell to enter the cell--not viruses that use the CXCR4 receptor, which often evolve later in HIV infection.