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CCR5

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.01 sec.
CCR5
A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS


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There certain drugs that block CCR5, and other teams are testing gene therapies to restock patients' blood with cells engineered to not produce CCR5.
Topics of the research and review papers include Nijmegen Breakage Syndrome, models of genetic and physiological heterogeneity, polymorphisms in CCR5 chemokine receptor genes, genetic anticipation, inheritance in mammal litter sizes in different populations, heritable and molecular genetic variation in mate choice and mating-related genes, osteogenesis imperfecta, tuberous sclerosis complex, and findings in Danon disease, a rare X-linked dominant disorder.
Three separate sources of growth are expected to drive Monogram's 2009 revenues: Increased sales of Trofile due to its clinically proven high level of sensitivity for selecting appropriate patients for CCR5 therapy and an increasingly positive profile for Selzentry, Pfizer's CCR5 antagonist, as a treatment option for a broad group of treatment-experienced HIV patients.
 
 
 
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