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CCR5 |
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CCR5 A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed. Mentioned in: AIDS How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The mutation that prevents CCR5 production renders 1 percent of whites highly resistant to infection by HIV but hasn't been found in other races. Three different experimental drugs that inhibit HIV by the same mechanism (blocking its use of the CCR5 co-receptor) have run into problems recently in clinical trials. The review contains a discussion of the HIV-1 phenotypic variants defined by their use of the CCR5 or CXCR4 co-receptors. |
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