CCR4


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CCR4

A gene on chromosome 3p24 that encodes a G protein-coupled receptor for C-C-type chemokines (MIP-1, RANTES, TARC and MCP-1). CCR4 is a high-affinity receptor for the C-C-type chemokines CCL17/TARC and CCL22/MDC; its activity is mediated by Gi proteins, which activate phosphatidylinositol-calcium second messengers.
References in periodicals archive ?
Anaplastic large cell lymphoma has a Th2 cytokine receptor profile with expression of CCR3 and CCR4 and production of IL-4 but not IFN[gamma].
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.
In this study, we investigated the hypothesis that Th2 specific cytokines IL-10, IL-4 and their cognate receptors and Th2 specific chemokine CCL-17(TARC) and its cognate receptor CCR4 are significantly up-regulated in prostate adenocarcinoma cell lines.
First CCR4 Targeted Antibody to Reach the Market 4.