CCR3


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CCR3

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for C-C-type chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5). It is highly expressed in eosinophils and basophils, as well as in TH1 cells, TH2 cells and airway epithelial cells; it may contribute to the accumulation and activation of eosinophils and other inflammatory cells in airways allergies, and is also an entry co-receptor for HIV-1.
References in periodicals archive ?
An exciting implication of this study was that the CCR3 protein could be detected in early abnormal blood vessel growth, giving us the opportunity to prevent structural damage to the retina and preserve vision," Hartnett added.
They detected the presence of the CCR3 protein in eye tissue from humans with AMD but not in that of individuals of similar age who did not have the disease.
When they blocked CCR3, either with drugs or through genetic engineering, they saw a decrease in the generation of abnormal blood vessels.
CCR3 and CCR5 are cell-surface receptors for chemokines, chemical signals used by the immune system to direct leukocytes to inflamed or infected tissue.
The Cell paper published by the LeukoSite, Dana-Farber and Children's Hospital team details how HIV uses the primary HIV receptor, CD4, together with either CCR3, CCR5 or a third coreceptor called "fusin" to enter and infect leukocytes.
Tryptase-chymase doublepositive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines.
Determination of CD69 and CCR3 surface expression were assessed using flow cytometry and FITC-labeled anti-CD69 and APC-labeled anti-CCR3 APC mAbs (ebioscience, Frankfurt, Getmany).
To investigate whether Gencydo[R]influenced the expression of the eotaxin receptor CCR3 on human eosinophils, we assessed CCR3 expression by using flow cytometry (Fig.
Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.
RANTES [2] (which stands for regulated on activation, normal T-cell expressed and secreted) binds to CCR1, CCR3, CCR5, and DARC receptors and correspondingly has an integral role in inflammation, cell recruitment, and T-cell activation.
Tat protein is an HIV-1 encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human Fc epsilon R+ cells.