CCR-5 | definition of CCR-5 by Medical dictionary
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CCR5 A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.
CCR-5 CMKBR2, CC CKR2, ChemR13 Cell biology A 40 kD receptor encoded on chromosome 3q21; CCR-5 is a coreceptor for SIV and HIV which, with CD4, provides the portal for HIV entry into macrophages Ligands MIP-1a, MIP-1b, RANTES. See AIDS, Coreceptor, HIV.
CCR-5 AIDS, Molecular medicine The gene that encodes CCR-5 which, when mutated, encodes a defective receptor protein incapable of being infected with HIV. See AIDS, CXCR4, HIV.
References in periodicals archive
Host genes and HIV: the role of the chemokine receptor gene CCR-5 and its alleles (32 CCR-5).
The role of mutant CCR-5 allele in HIV-1 transmission and disease progression.
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.