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CCR-5

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CCR-5
CMKBR2, CC CKR2, ChemR13 Cell biology A 40 kD receptor encoded on chromosome 3q21; CCR-5 is a coreceptor for SIV and HIV which, with CD4, provides the portal for HIV entry into macrophages Ligands MIP-1a, MIP-1b, RANTES. See AIDS, Coreceptor, HIV.

CCR-5
AIDS, Molecular medicine The gene that encodes CCR-5 which, when mutated, encodes a defective receptor protein incapable of being infected with HIV. See AIDS, CXCR4, HIV.


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However, no such mutation is seen in Japanese, Native Americans, Chinese, Africans, and Tamil Indians, which suggests that in these groups either resistance to HIV infection is not present or factors other than mutated CCR-5 are in operation.
 
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