CCNF


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CCNF

A gene on chromosome 16p13.3 that encodes a member of the cyclin family which regulates cell cycle transitions by binding and activating cyclin-dependent protein kinases. CCNF also belongs to the F-box protein family that constitutes a subunit of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.
References in periodicals archive ?
Mediastinal extension of CCNF is a very serious complication that can lead to mediastinitis, pericarditis, pleural or pericardial effusion, empyema, pneumonitis, cardiac tamponade, and esophageal bleeding.
In a review of cases of CCNF with thoracic extension published in 2001, Bahu et al reported an overall mortality rate of 35%.
On initial presentation, infection in CCNF patients must be differentiated from cellulitis, which is sometimes accompanied by erythema.